Frei E - Search Results

1

Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.

Stiborova M, Rupertova M, Schmeiser HH, Frei E. Stiborova M, et al. Among authors: frei e. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. doi: 10.5507/bp.2006.002. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006. PMID: 16936898 Review.

2

Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.

Stiborová M, Stiborová-Rupertová M, Borek-Dohalská L, Wiessler M, Frei E. Stiborová M, et al. Among authors: frei e. Chem Res Toxicol. 2003 Jan;16(1):38-47. doi: 10.1021/tx0200818. Chem Res Toxicol. 2003. PMID: 12693029

3

DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.

Stiborová M, Breuer A, Aimová D, Stiborová-Rupertová M, Wiessler M, Frei E. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2003 Dec 20;107(6):885-90. doi: 10.1002/ijc.11511. Int J Cancer. 2003. PMID: 14601046 Free article.

4

Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.

Miksanová M, Sulc M, Rýdlová H, Schmeiser HH, Frei E, Stiborová M. Miksanová M, et al. Among authors: frei e. Chem Res Toxicol. 2004 May;17(5):663-71. doi: 10.1021/tx0499721. Chem Res Toxicol. 2004. PMID: 15144223

5

The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.

Stiborová M, Sejbal J, Borek-Dohalská L, Aimová D, Poljaková J, Forsterová K, Rupertová M, Wiesner J, Hudecek J, Wiessler M, Frei E. Stiborová M, et al. Among authors: frei e. Cancer Res. 2004 Nov 15;64(22):8374-80. doi: 10.1158/0008-5472.CAN-04-2202. Cancer Res. 2004. PMID: 15548707

6

Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine.

Stiborová M, Miksanová M, Sulc M, Rýdlová H, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2005 Sep 20;116(5):667-78. doi: 10.1002/ijc.21122. Int J Cancer. 2005. PMID: 15828049 Free article.

7

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.

Stiborová M, Sopko B, Hodek P, Frei E, Schmeiser HH, Hudecek J. Stiborová M, et al. Among authors: frei e. Cancer Lett. 2005 Nov 18;229(2):193-204. doi: 10.1016/j.canlet.2005.06.038. Epub 2005 Aug 24. Cancer Lett. 2005. PMID: 16125300

8

Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.

Stiborová M, Arlt VM, Henderson CJ, Wolf CR, Frei E, Schmeiser HH, Phillips DH. Stiborová M, et al. Among authors: frei e. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):191-7. doi: 10.5507/bp.2005.025. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601755 Review.

9

Oxidation of an antitumor drug ellipticine by peroxidases.

Poljaková J, Forsterová K, Sulc M, Frei E, Stiborová M. Poljaková J, et al. Among authors: frei e. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):449-53. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601808

10

The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.

Stiborová M, Dracínská H, Hájková J, Kaderábková P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: frei e. Drug Metab Dispos. 2006 Aug;34(8):1398-405. doi: 10.1124/dmd.106.009373. Epub 2006 May 19. Drug Metab Dispos. 2006. PMID: 16714372

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