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Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.
Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC. Love MS, et al. Among authors: freeman kb. Cell Host Microbe. 2012 Dec 13;12(6):815-23. doi: 10.1016/j.chom.2012.10.017. Cell Host Microbe. 2012. PMID: 23245326 Free PMC article.
De novo design of self-assembling foldamers that inhibit heparin-protein interactions.
Montalvo GL, Zhang Y, Young TM, Costanzo MJ, Freeman KB, Wang J, Clements DJ, Magavern E, Kavash RW, Scott RW, Liu D, Degrado WF. Montalvo GL, et al. Among authors: freeman kb. ACS Chem Biol. 2014 Apr 18;9(4):967-75. doi: 10.1021/cb500026x. Epub 2014 Feb 11. ACS Chem Biol. 2014. PMID: 24491145 Free PMC article.
Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents.
Rubin H, Selwood T, Yano T, Weaver DG, Loughran HM, Costanzo MJ, Scott RW, Wrobel JE, Freeman KB, Reitz AB. Rubin H, et al. Among authors: freeman kb. Bioorg Med Chem Lett. 2015 Jan 15;25(2):378-83. doi: 10.1016/j.bmcl.2014.11.020. Epub 2014 Nov 22. Bioorg Med Chem Lett. 2015. PMID: 25496770
Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism.
Menzel LP, Chowdhury HM, Masso-Silva JA, Ruddick W, Falkovsky K, Vorona R, Malsbary A, Cherabuddi K, Ryan LK, DiFranco KM, Brice DC, Costanzo MJ, Weaver D, Freeman KB, Scott RW, Diamond G. Menzel LP, et al. Among authors: freeman kb. Sci Rep. 2017 Jun 28;7(1):4353. doi: 10.1038/s41598-017-04462-6. Sci Rep. 2017. PMID: 28659617 Free PMC article.
Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406.
Baugh SDP, Chaly A, Weaver DG, Whitman DB, Pelletier JC, Bian H, Freeman KB, Reitz AB, Scott RW. Baugh SDP, et al. Among authors: freeman kb. Med Chem Res. 2023 May 30:1-17. doi: 10.1007/s00044-023-03083-1. Online ahead of print. Med Chem Res. 2023. PMID: 37362318 Free PMC article.
158 results