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A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD.
DiLillo KM, Norman KC, Freeman CM, Christenson SA, Alexis NE, Anderson WH, Barjaktarevic IZ, Barr RG, Comellas AP, Bleecker ER, Boucher RC, Couper DJ, Criner GJ, Doerschuk CM, Wells JM, Han MK, Hoffman EA, Hansel NN, Hastie AT, Kaner RJ, Krishnan JA, Labaki WW, Martinez FJ, Meyers DA, O'Neal WK, Ortega VE, Paine R 3rd, Peters SP, Woodruff PG, Cooper CB, Bowler RP, Curtis JL, Arnold KB; SPIROMICS investigators. DiLillo KM, et al. Among authors: freeman cm. Sci Rep. 2023 May 22;13(1):8228. doi: 10.1038/s41598-023-32216-0. Sci Rep. 2023. PMID: 37217548 Free PMC article.
Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15.
Freeman CM, Han MK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak TJ, Sonstein J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Freeman CM, et al. J Immunol. 2010 Jun 1;184(11):6504-13. doi: 10.4049/jimmunol.1000006. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427767 Free PMC article.
Analysis of the lung microbiome in the "healthy" smoker and in COPD.
Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB. Erb-Downward JR, et al. Among authors: freeman cm. PLoS One. 2011 Feb 22;6(2):e16384. doi: 10.1371/journal.pone.0016384. PLoS One. 2011. PMID: 21364979 Free PMC article. Clinical Trial.
Lung CD8+ T cells in COPD have increased expression of bacterial TLRs.
Freeman CM, Martinez FJ, Han MK, Washko GR Jr, McCubbrey AL, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Freeman CM, et al. Respir Res. 2013 Feb 1;14(1):13. doi: 10.1186/1465-9921-14-13. Respir Res. 2013. PMID: 23374856 Free PMC article. Clinical Trial.
115 results