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Tumor immune evasion arises through loss of TNF sensitivity.
Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J. Kearney CJ, et al. Among authors: freeman aj. Sci Immunol. 2018 May 18;3(23):eaar3451. doi: 10.1126/sciimmunol.aar3451. Sci Immunol. 2018. PMID: 29776993
Antagonism of IAPs Enhances CAR T-cell Efficacy.
Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J. Michie J, et al. Among authors: freeman aj. Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16. Cancer Immunol Res. 2019. PMID: 30651288
Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion.
Freeman AJ, Vervoort SJ, Ramsbottom KM, Kelly MJ, Michie J, Pijpers L, Johnstone RW, Kearney CJ, Oliaro J. Freeman AJ, et al. Cell Rep. 2019 Sep 10;28(11):2784-2794.e5. doi: 10.1016/j.celrep.2019.08.017. Cell Rep. 2019. PMID: 31509742 Free article.
DOCK8 Drives Src-Dependent NK Cell Effector Function.
Kearney CJ, Vervoort SJ, Ramsbottom KM, Freeman AJ, Michie J, Peake J, Casanova JL, Picard C, Tangye SG, Ma CS, Johnstone RW, Randall KL, Oliaro J. Kearney CJ, et al. Among authors: freeman aj. J Immunol. 2017 Aug 9:ji1700751. doi: 10.4049/jimmunol.1700751. Online ahead of print. J Immunol. 2017. PMID: 28794229
MAIT cells regulate NK cell-mediated tumor immunity.
Petley EV, Koay HF, Henderson MA, Sek K, Todd KL, Keam SP, Lai J, House IG, Li J, Zethoven M, Chen AXY, Oliver AJ, Michie J, Freeman AJ, Giuffrida L, Chan JD, Pizzolla A, Mak JYW, McCulloch TR, Souza-Fonseca-Guimaraes F, Kearney CJ, Millen R, Ramsay RG, Huntington ND, McCluskey J, Oliaro J, Fairlie DP, Neeson PJ, Godfrey DI, Beavis PA, Darcy PK. Petley EV, et al. Among authors: freeman aj. Nat Commun. 2021 Aug 6;12(1):4746. doi: 10.1038/s41467-021-25009-4. Nat Commun. 2021. PMID: 34362900 Free PMC article.
Comparative immune phenotypic analysis of cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in immune-competent individuals: proportional representation of CD8+ T-cells but not FoxP3+ Regulatory T-cells is associated with disease stage.
Freeman A, Bridge JA, Maruthayanar P, Overgaard NH, Jung JW, Simpson F, Prow TW, Soyer HP, Frazer IH, Freeman M, Wells JW. Freeman A, et al. PLoS One. 2014 Oct 23;9(10):e110928. doi: 10.1371/journal.pone.0110928. eCollection 2014. PLoS One. 2014. PMID: 25340823 Free PMC article.
356 results