Freel Meyers CL - Search Results

1

Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations.

Curley P, Hobson JJ, Liptrott NJ, Makarov E, Al-Khouja A, Tatham L, David CAW, Box H, Neary M, Sharp J, Pertinez H, Meyers D, Flexner C, Freel Meyers CL, Poluektova L, Rannard S, Owen A. Curley P, et al. Among authors: freel meyers cl. Pharmaceutics. 2023 Jun 27;15(7):1835. doi: 10.3390/pharmaceutics15071835. Pharmaceutics. 2023. PMID: 37514020 Free PMC article.

2

Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV.

Rajoli RK, Back DJ, Rannard S, Freel Meyers CL, Flexner C, Owen A, Siccardi M. Rajoli RK, et al. Among authors: freel meyers cl. Clin Pharmacokinet. 2015 Jun;54(6):639-50. doi: 10.1007/s40262-014-0227-1. Clin Pharmacokinet. 2015. PMID: 25523214 Free PMC article.

3

Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).

Armstrong CM, Meyers DJ, Imlay LS, Freel Meyers C, Odom AR. Armstrong CM, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5511-9. doi: 10.1128/AAC.00602-15. Epub 2015 Jun 29. Antimicrob Agents Chemother. 2015. PMID: 26124156 Free PMC article.

4

Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase.

Bartee D, Morris F, Al-Khouja A, Freel Meyers CL. Bartee D, et al. Among authors: freel meyers cl. Chembiochem. 2015 Aug 17;16(12):1771-81. doi: 10.1002/cbic.201500119. Epub 2015 Jul 15. Chembiochem. 2015. PMID: 26174207 Free PMC article.

5

Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants.

Shakil A, Hern FY, Liu C, Temburnikar K, Chambon P, Liptrott N, McDonald TO, Neary M, Owen A, Freel Meyers C, Rannard SP. Shakil A, et al. J Mater Chem B. 2022 Jun 15;10(23):4395-4404. doi: 10.1039/d2tb00825d. J Mater Chem B. 2022. PMID: 35604111 Free PMC article.

6

Pharmacological activation of myosin II paralogs to correct cell mechanics defects.

Surcel A, Ng WP, West-Foyle H, Zhu Q, Ren Y, Avery LB, Krenc AK, Meyers DJ, Rock RS, Anders RA, Freel Meyers CL, Robinson DN. Surcel A, et al. Among authors: meyers dj, freel meyers cl. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1428-33. doi: 10.1073/pnas.1412592112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605895 Free PMC article.

7

DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies.

Chen EC, Freel Meyers CL. Chen EC, et al. Among authors: freel meyers cl. Antibiotics (Basel). 2023 Apr 1;12(4):692. doi: 10.3390/antibiotics12040692. Antibiotics (Basel). 2023. PMID: 37107054 Free PMC article.

8

Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism.

Johnston ML, Freel Meyers CL. Johnston ML, et al. Among authors: freel meyers cl. Biochemistry. 2021 Mar 30;60(12):929-939. doi: 10.1021/acs.biochem.1c00019. Epub 2021 Mar 4. Biochemistry. 2021. PMID: 33660509 Free PMC article.

9

Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction.

Johnston ML, Bonett EM, DeColli AA, Freel Meyers CL. Johnston ML, et al. Among authors: freel meyers cl. Biochemistry. 2022 Sep 6;61(17):1810-1823. doi: 10.1021/acs.biochem.2c00274. Epub 2022 Aug 23. Biochemistry. 2022. PMID: 35998648 Free PMC article.

10

Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2- C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens.

Bartee D, Wheadon MJ, Freel Meyers CL. Bartee D, et al. Among authors: freel meyers cl. J Org Chem. 2018 Sep 7;83(17):9580-9591. doi: 10.1021/acs.joc.8b00686. Epub 2018 Jun 11. J Org Chem. 2018. PMID: 29870251 Free PMC article.

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