Fraser DA - Search Results

1

Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia.

Kastelein JJ, Hallén J, Vige R, Fraser DA, Zhou R, Hustvedt SO, Orloff DG, Bays HE. Kastelein JJ, et al. Among authors: fraser da. Cardiology. 2016;135(1):3-12. doi: 10.1159/000445047. Epub 2016 May 4. Cardiology. 2016. PMID: 27160246 Free article. Clinical Trial.

2

Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial.

Bays HE, Hallén J, Vige R, Fraser D, Zhou R, Hustvedt SO, Orloff DG, Kastelein JJ. Bays HE, et al. J Clin Lipidol. 2016 Jan-Feb;10(1):181-91.e1-2. doi: 10.1016/j.jacl.2015.10.012. Epub 2015 Nov 14. J Clin Lipidol. 2016. PMID: 26892135 Clinical Trial.

3

Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative.

Stokman G, van den Hoek AM, Denker Thorbekk D, Pieterman EJ, Skovgård Veidal S, Basta B, Iruarrizaga-Lejarreta M, van der Hoorn JW, Verschuren L, Berbée JFP, Rensen PCN, Skjaeret T, Alonso C, Feigh M, Kastelein JJP, Friedman SL, Princen HMG, Fraser DA. Stokman G, et al. Among authors: fraser da. Liver Int. 2020 Nov;40(11):2860-2876. doi: 10.1111/liv.14643. Liver Int. 2020. PMID: 32841505 Free PMC article.

4

A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH.

Fraser DA, Wang X, Lund J, Nikolić N, Iruarrizaga-Lejarreta M, Skjaeret T, Alonso C, Kastelein JJP, Rustan AC, Kim YO, Schuppan D. Fraser DA, et al. J Hepatol. 2022 Apr;76(4):800-811. doi: 10.1016/j.jhep.2021.12.004. Epub 2021 Dec 13. J Hepatol. 2022. PMID: 34915054

5

Structurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease.

Secor JD, Cho BS, Yu LJ, Pan A, Ko VH, Dao DT, Feigh M, Anez-Bustillos L, Fell GL, Fraser DA, Gura KM, Puder M. Secor JD, et al. Among authors: fraser da. Lipids. 2022 Jul;57(4-5):241-255. doi: 10.1002/lipd.12351. Epub 2022 Jul 1. Lipids. 2022. PMID: 35778847 Free PMC article.

6

Icosabutate: targeting metabolic and inflammatory pathways for the treatment of NASH.

Fraser DA, Harrison SA, Schuppan D. Fraser DA, et al. Expert Opin Investig Drugs. 2022 Dec;31(12):1269-1278. doi: 10.1080/13543784.2022.2159804. Epub 2022 Dec 28. Expert Opin Investig Drugs. 2022. PMID: 36527256

7

A Medium-Chain Fatty Acid Analogue Prevents Intestinal Failure-Associated Liver Disease in Preterm Yorkshire Piglets.

Fligor SC, Tsikis ST, Hirsch TI, Pan A, Moskowitzova K, Rincon-Cruz L, Whitlock AE, Mitchell PD, Nedder AP, Gura KM, Fraser DA, Puder M. Fligor SC, et al. Among authors: fraser da. Gastroenterology. 2023 Sep;165(3):733-745.e9. doi: 10.1053/j.gastro.2023.05.035. Epub 2023 May 30. Gastroenterology. 2023. PMID: 37263310 Free article.

8

A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis.

Cho BS, Fligor SC, Fell GL, Secor JD, Tsikis ST, Pan A, Yu LJ, Ko VH, Dao DT, Anez-Bustillos L, Hirsch TI, Lund J, Rustan AC, Fraser DA, Gura KM, Puder M. Cho BS, et al. Among authors: fraser da. PLoS One. 2023 Dec 1;18(12):e0295244. doi: 10.1371/journal.pone.0295244. eCollection 2023. PLoS One. 2023. PMID: 38039287 Free PMC article.

9

Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice.

van den Hoek AM, Pieterman EJ, van der Hoorn JW, Iruarrizaga-Lejarreta M, Alonso C, Verschuren L, Skjæret T, Princen HMG, Fraser DA. van den Hoek AM, et al. Among authors: fraser da. Hepatol Commun. 2019 Dec 24;4(2):193-207. doi: 10.1002/hep4.1453. eCollection 2020 Feb. Hepatol Commun. 2019. PMID: 32025605 Free PMC article.

10

Multimetallic Permethylpentalene Hydride Complexes.

Fraser DAX, Turner ZR, Cooper RT, Buffet JC, Green JC, O'Hare D. Fraser DAX, et al. Inorg Chem. 2022 Aug 8;61(31):12207-12218. doi: 10.1021/acs.inorgchem.2c01267. Epub 2022 Jul 25. Inorg Chem. 2022. PMID: 35878422 Free PMC article.

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