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High-performance liquid chromatographic assay for the determination of the novel C-Seco-taxane derivative (IDN 5390) in mouse plasma.
Zaffaroni M, Frapolli R, Colombo T, Fruscio R, Bombardelli E, Morazzoni P, Riva A, D'Incalci M, Zucchetti M. Zaffaroni M, et al. Among authors: frapolli r. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15;780(1):93-8. doi: 10.1016/s1570-0232(02)00436-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 12383484
Fetal bovine serum, but not human serum, inhibits the in vitro cytotoxicity of ET-743 (Yondelis, trabectedin), an example of potential problems for extrapolation of active drug concentrations from in vitro studies.
Tognon G, Frapolli R, Zaffaroni M, Erba E, Zucchetti M, Faircloth GT, D'Incalci M. Tognon G, et al. Among authors: frapolli r. Cancer Chemother Pharmacol. 2004 Jan;53(1):89-90. doi: 10.1007/s00280-003-0704-y. Epub 2003 Oct 28. Cancer Chemother Pharmacol. 2004. PMID: 14586558 No abstract available.
Clindamycin-paclitaxel pharmacokinetic interaction in ovarian cancer patients.
Fruscio R, Lissoni AA, Frapolli R, Corso S, Mangioni C, D'Incalci M, Zucchetti M. Fruscio R, et al. Among authors: frapolli r. Cancer Chemother Pharmacol. 2006 Sep;58(3):319-25. doi: 10.1007/s00280-005-0160-y. Epub 2005 Dec 13. Cancer Chemother Pharmacol. 2006. PMID: 16362296 Clinical Trial.
Pharmacokinetics and metabolism in mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a new oral c-seco-taxane derivative with antiangiogenic property effective on paclitaxel-resistant tumors.
Frapolli R, Marangon E, Zaffaroni M, Colombo T, Falcioni C, Bagnati R, Simone M, D'Incalci M, Manzotti C, Fontana G, Morazzoni P, Zucchetti M. Frapolli R, et al. Drug Metab Dispos. 2006 Dec;34(12):2028-35. doi: 10.1124/dmd.106.012153. Epub 2006 Sep 8. Drug Metab Dispos. 2006. PMID: 16963486
Biological properties of IDN5174, a new synthetic camptothecin with the open lactone ring.
Beretta GL, Petrangolini G, De Cesare M, Pratesi G, Perego P, Tinelli S, Tortoreto M, Zucchetti M, Frapolli R, Bello E, Manzotti C, Fontana G, Bombardelli E, Battaglia A, Samorì C, Zunino F. Beretta GL, et al. Among authors: frapolli r. Cancer Res. 2006 Nov 15;66(22):10976-82. doi: 10.1158/0008-5472.CAN-06-2158. Cancer Res. 2006. PMID: 17108136
82 results