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Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Rodrigues TS, et al. Among authors: frantz fg. J Exp Med. 2021 Mar 1;218(3):e20201707. doi: 10.1084/jem.20201707. J Exp Med. 2021. PMID: 33231615 Free PMC article.
Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition.
de Carvalho RVH, Lima-Junior DS, da Silva MVG, Dilucca M, Rodrigues TS, Horta CV, Silva ALN, da Silva PF, Frantz FG, Lorenzon LB, Souza MM, Almeida F, Cantanhêde LM, Ferreira RGM, Cruz AK, Zamboni DS. de Carvalho RVH, et al. Among authors: frantz fg. Nat Commun. 2019 Nov 21;10(1):5273. doi: 10.1038/s41467-019-13356-2. Nat Commun. 2019. PMID: 31754185 Free PMC article.
Publisher Correction: Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition.
de Carvalho RVH, Lima-Junior DS, da Silva MVG, Dilucca M, Rodrigues TS, Horta CV, Silva ALN, da Silva PF, Frantz FG, Lorenzon LB, Souza MM, Almeida F, Cantanhêde LM, Ferreira RGM, Cruz AK, Zamboni DS. de Carvalho RVH, et al. Among authors: frantz fg. Nat Commun. 2020 Jan 7;11(1):203. doi: 10.1038/s41467-019-13900-0. Nat Commun. 2020. PMID: 31907351 Free PMC article.
sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.
da Silva-Neto PV, de Carvalho JCS, Pimentel VE, Pérez MM, Toro DM, Fraga-Silva TFC, Fuzo CA, Oliveira CNS, Rodrigues LC, Argolo JGM, Carmona-Garcia I, Neto NT, Souza COS, Fernandes TM, Bastos VAF, Degiovani AM, Constant LF, Ostini FM, Feitosa MR, Parra RS, Vilar FC, Gaspar GG, da Rocha JJR, Feres O, Frantz FG, Gerlach RF, Maruyama SR, Russo EMS, Viana AL, Fernandes APM, Santos IKFM, Bonato VLD, Boechat AL, Malheiro A, Sadikot RT, Dias-Baruffi M, Cardoso CRB, Faccioli LH, Sorgi CA, On Behalf Of The Imunocovid Study Group. da Silva-Neto PV, et al. Among authors: frantz fg. Viruses. 2021 Dec 15;13(12):2521. doi: 10.3390/v13122521. Viruses. 2021. PMID: 34960790 Free PMC article.
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
de Almeida L, da Silva ALN, Rodrigues TS, Oliveira S, Ishimoto AY, Seribelli AA, Becerra A, Andrade WA, Ataide MA, Caetano CCS, de Sá KSG, Pelisson N, Martins RB, de Paula Souza J, Arruda E, Batah SS, Castro R, Frantz FG, Cunha FQ, Cunha TM, Fabro AT, Cunha LD, Louzada-Junior P, de Oliveira RDR, Zamboni DS. de Almeida L, et al. Among authors: frantz fg. Sci Adv. 2022 Sep 16;8(37):eabo5400. doi: 10.1126/sciadv.abo5400. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103544 Free PMC article.
CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.
Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, Lopes LS, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS. Rodrigues TS, et al. Among authors: frantz fg. J Infect Dis. 2023 Jun 15;227(12):1364-1375. doi: 10.1093/infdis/jiad037. J Infect Dis. 2023. PMID: 36763010
COVID-19 inactivated and non-replicating viral vector vaccines induce regulatory training phenotype in human monocytes under epigenetic control.
Antunes MDSM, Sugiyama FHC, Gravina HD, Castro RC, Mercado FJR, de Lima JO, Fontanari C, Frantz FG. Antunes MDSM, et al. Among authors: frantz fg. Front Cell Infect Microbiol. 2023 Jul 14;13:1200789. doi: 10.3389/fcimb.2023.1200789. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37520439 Free PMC article.
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