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Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors.
Knopf P, Stowbur D, Hoffmann SHL, Hermann N, Maurer A, Bucher V, Poxleitner M, Tako B, Sonanini D, Krishnamachary B, Sinharay S, Fehrenbacher B, Gonzalez-Menendez I, Reckmann F, Bomze D, Flatz L, Kramer D, Schaller M, Forchhammer S, Bhujwalla ZM, Quintanilla-Martinez L, Schulze-Osthoff K, Pagel MD, Fransen MF, Röcken M, Martins AF, Pichler BJ, Ghoreschi K, Kneilling M. Knopf P, et al. Among authors: fransen mf. Mol Cancer. 2023 Dec 15;22(1):207. doi: 10.1186/s12943-023-01900-0. Mol Cancer. 2023. PMID: 38102680 Free PMC article.
PD-L1 immune suppression in cancer: Tumor cells or host cells?
Kleinovink JW, van Hall T, Ossendorp F, Fransen MF. Kleinovink JW, et al. Among authors: fransen mf. Oncoimmunology. 2017 May 12;6(7):e1325982. doi: 10.1080/2162402X.2017.1325982. eCollection 2017. Oncoimmunology. 2017. PMID: 28811961 Free PMC article.
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy.
Kleinovink JW, Marijt KA, Schoonderwoerd MJA, van Hall T, Ossendorp F, Fransen MF. Kleinovink JW, et al. Among authors: fransen mf. Oncoimmunology. 2017 Feb 21;6(4):e1294299. doi: 10.1080/2162402X.2017.1294299. eCollection 2017. Oncoimmunology. 2017. PMID: 28507803 Free PMC article.
FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model.
Sow HS, Benonisson H, Breukel C, Visser R, Verhagen OJHM, Bentlage AEH, Brouwers C, Claassens JWC, Linssen MM, Camps M, van Hall T, Ossendorp F, Fransen MF, Vidarsson G, Verbeek JS. Sow HS, et al. Among authors: fransen mf. Int J Cancer. 2019 Jan 15;144(2):345-354. doi: 10.1002/ijc.31899. Epub 2018 Nov 12. Int J Cancer. 2019. PMID: 30259976 Free article.
51 results