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Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.
Gillotin F, Chiap P, Frédérich M, Van Heugen JC, Francotte P, Lebrun P, Pirotte B, de Tullio P. Gillotin F, et al. Among authors: francotte p. Drug Metab Dispos. 2010 Feb;38(2):232-40. doi: 10.1124/dmd.109.028928. Epub 2009 Oct 29. Drug Metab Dispos. 2010. PMID: 19875500
Dimeric polyphenols to pave the way for new antimalarial drugs.
Degotte G, Pendeville H, Di Chio C, Ettari R, Pirotte B, Frédérich M, Francotte P. Degotte G, et al. Among authors: francotte p. RSC Med Chem. 2023 Feb 10;14(4):715-733. doi: 10.1039/d2md00392a. eCollection 2023 Apr 26. RSC Med Chem. 2023. PMID: 37122550 Free PMC article.
New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P. Francotte P, et al. J Med Chem. 2010 Feb 25;53(4):1700-11. doi: 10.1021/jm901495t. J Med Chem. 2010. PMID: 20108934 Free article.
36 results