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PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, Vignali DAA, Freeman GJ, Sharpe AH. Tan CL, et al. Among authors: francisco lm. J Exp Med. 2021 Jan 4;218(1):e20182232. doi: 10.1084/jem.20182232. J Exp Med. 2021. PMID: 33045061 Free PMC article.
PD-1 and its ligands in T-cell immunity.
Keir ME, Francisco LM, Sharpe AH. Keir ME, et al. Among authors: francisco lm. Curr Opin Immunol. 2007 Jun;19(3):309-14. doi: 10.1016/j.coi.2007.04.012. Epub 2007 Apr 12. Curr Opin Immunol. 2007. PMID: 17433872 Review.
The PD-1 pathway in tolerance and autoimmunity.
Francisco LM, Sage PT, Sharpe AH. Francisco LM, et al. Immunol Rev. 2010 Jul;236:219-42. doi: 10.1111/j.1600-065X.2010.00923.x. Immunol Rev. 2010. PMID: 20636820 Free PMC article. Review.
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Quigley M, et al. Nat Med. 2010 Oct;16(10):1147-51. doi: 10.1038/nm.2232. Epub 2010 Oct 3. Nat Med. 2010. PMID: 20890291 Free PMC article.
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.
Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. Sharma MD, et al. Among authors: francisco lm. Sci Adv. 2015 Nov 6;1(10):e1500845. doi: 10.1126/sciadv.1500845. eCollection 2015 Nov. Sci Adv. 2015. PMID: 26601142 Free PMC article.
40 results