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Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.
Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W, Waisman A. Pinteaux E, et al. Among authors: francis s. J Mol Med (Berl). 2020 Jul;98(7):923-930. doi: 10.1007/s00109-020-01928-5. Epub 2020 May 29. J Mol Med (Berl). 2020. PMID: 32468079 Free PMC article. Review.
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C, Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK. Gomez D, et al. Among authors: francis se. Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038/s41591-018-0124-5. Epub 2018 Jul 23. Nat Med. 2018. PMID: 30038218 Free PMC article.
Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons.
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, Császár E, Nyiri G, Papaemmanouil A, Waisman A, Müller W, Schwaninger M, Rothwell N, Francis S, Pinteaux E, Denés A, Allan SM. Wong R, et al. Among authors: francis s. Brain Behav Immun. 2019 Feb;76:126-138. doi: 10.1016/j.bbi.2018.11.012. Epub 2018 Nov 16. Brain Behav Immun. 2019. PMID: 30453020 Free PMC article.
Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms.
Helyes Z, Tékus V, Szentes N, Pohóczky K, Botz B, Kiss T, Kemény Á, Környei Z, Tóth K, Lénárt N, Ábrahám H, Pinteaux E, Francis S, Sensi S, Dénes Á, Goebel A. Helyes Z, et al. Among authors: francis s. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13067-13076. doi: 10.1073/pnas.1820168116. Epub 2019 Jun 10. Proc Natl Acad Sci U S A. 2019. PMID: 31182576 Free PMC article.
Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction.
Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE, Ainscough JF, Pinteaux E, Drinkhill MJ, Turner NA. Bageghni SA, et al. Among authors: francis s. JCI Insight. 2019 Aug 8;5(17):e125074. doi: 10.1172/jci.insight.125074. JCI Insight. 2019. PMID: 31393855 Free PMC article.
IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer.
Tulotta C, Lefley DV, Moore CK, Amariutei AE, Spicer-Hadlington AR, Quayle LA, Hughes RO, Ahmed K, Cookson V, Evans CA, Vadakekolathu J, Heath P, Francis S, Pinteaux E, Pockley AG, Ottewell PD. Tulotta C, et al. Among authors: francis s. NPJ Breast Cancer. 2021 Jul 21;7(1):95. doi: 10.1038/s41523-021-00305-w. NPJ Breast Cancer. 2021. PMID: 34290237 Free PMC article.
Tribbles-2 is a novel regulator of inflammatory activation of monocytes.
Eder K, Guan H, Sung HY, Ward J, Angyal A, Janas M, Sarmay G, Duda E, Turner M, Dower SK, Francis SE, Crossman DC, Kiss-Toth E. Eder K, et al. Int Immunol. 2008 Dec;20(12):1543-50. doi: 10.1093/intimm/dxn116. Epub 2008 Oct 24. Int Immunol. 2008. PMID: 18952906 Free PMC article.
1,408 results