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Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets.
Francis ME, Richardson B, McNeil M, Rioux M, Foley MK, Ge A, Pechous RD, Kindrachuk J, Cameron CM, Richardson C, Lew J, Cameron MJ, Gerdts V, Falzarano D, Kelvin AA. Francis ME, et al. bioRxiv [Preprint]. 2021 Jan 12:2021.01.12.426381. doi: 10.1101/2021.01.12.426381. bioRxiv. 2021. PMID: 33469587 Free PMC article. Updated. Preprint.
Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection as determined by serological study.
Foley MK, Searle SD, Toloue A, Booth R, Falkenham A, Falzarano D, Rubino S, Francis ME, McNeil M, Richardson C, LeBlanc J, Oldford S, Gerdts V, Andrew MK, McNeil SA, Clarke B, Rockwood K, Kelvin DJ, Kelvin AA. Foley MK, et al. Among authors: francis me. EClinicalMedicine. 2021 Jul;37:100975. doi: 10.1016/j.eclinm.2021.100975. Epub 2021 Jun 27. EClinicalMedicine. 2021. PMID: 34222846 Free PMC article.
SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney.
Francis ME, Goncin U, Kroeker A, Swan C, Ralph R, Lu Y, Etzioni AL, Falzarano D, Gerdts V, Machtaler S, Kindrachuk J, Kelvin AA. Francis ME, et al. PLoS Pathog. 2021 Jul 15;17(7):e1009705. doi: 10.1371/journal.ppat.1009705. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34265022 Free PMC article.
After the virus has cleared-Can preclinical models be employed for Long COVID research?
Jansen EB, Orvold SN, Swan CL, Yourkowski A, Thivierge BM, Francis ME, Ge A, Rioux M, Darbellay J, Howland JG, Kelvin AA. Jansen EB, et al. Among authors: francis me. PLoS Pathog. 2022 Sep 7;18(9):e1010741. doi: 10.1371/journal.ppat.1010741. eCollection 2022 Sep. PLoS Pathog. 2022. PMID: 36070309 Free PMC article. Review.
50 results