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Dissecting the biology of mTORC1 beyond rapamycin.
Yang G, Francis D, Krycer JR, Larance M, Zhang Z, Novotny CJ, Diaz-Vegas A, Shokat KM, James DE. Yang G, et al. Among authors: francis d. Sci Signal. 2021 Sep 21;14(701):eabe0161. doi: 10.1126/scisignal.abe0161. Epub 2021 Sep 21. Sci Signal. 2021. PMID: 34546793 Free PMC article.
RagC phosphorylation autoregulates mTOR complex 1.
Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE. Yang G, et al. Among authors: francis d. EMBO J. 2019 Feb 1;38(3):e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14. EMBO J. 2019. PMID: 30552228 Free PMC article.
Lactate production is a prioritized feature of adipocyte metabolism.
Krycer JR, Quek LE, Francis D, Fazakerley DJ, Elkington SD, Diaz-Vegas A, Cooke KC, Weiss FC, Duan X, Kurdyukov S, Zhou PX, Tambar UK, Hirayama A, Ikeda S, Kamei Y, Soga T, Cooney GJ, James DE. Krycer JR, et al. Among authors: francis d. J Biol Chem. 2020 Jan 3;295(1):83-98. doi: 10.1074/jbc.RA119.011178. Epub 2019 Nov 5. J Biol Chem. 2020. PMID: 31690627 Free PMC article.
Insulin signaling requires glucose to promote lipid anabolism in adipocytes.
Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, Nelson ME, Diaz-Vegas A, Humphrey SJ, Scalzo R, Hirayama A, Ikeda S, Shoji F, Suzuki K, Huynh K, Giles C, Varney B, Nagarajan SR, Hoy AJ, Soga T, Meikle PJ, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: francis d. J Biol Chem. 2020 Sep 18;295(38):13250-13266. doi: 10.1074/jbc.RA120.014907. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723868 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33518012
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt.
Su Z, Burchfield JG, Yang P, Humphrey SJ, Yang G, Francis D, Yasmin S, Shin SY, Norris DM, Kearney AL, Astore MA, Scavuzzo J, Fisher-Wellman KH, Wang QP, Parker BL, Neely GG, Vafaee F, Chiu J, Yeo R, Hogg PJ, Fazakerley DJ, Nguyen LK, Kuyucak S, James DE. Su Z, et al. Among authors: francis d. Nat Commun. 2019 Dec 2;10(1):5486. doi: 10.1038/s41467-019-13114-4. Nat Commun. 2019. PMID: 31792197 Free PMC article.
Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.
Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE. Nelson ME, et al. Among authors: francis d. EMBO J. 2019 Dec 16;38(24):e102578. doi: 10.15252/embj.2019102578. Epub 2019 Aug 5. EMBO J. 2019. PMID: 31381180 Free PMC article.
Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry.
Nelson ME, Parker BL, Burchfield JG, Hoffman NJ, Needham EJ, Cooke KC, Naim T, Sylow L, Ling NX, Francis D, Norris DM, Chaudhuri R, Oakhill JS, Richter EA, Lynch GS, Stöckli J, James DE. Nelson ME, et al. Among authors: francis d. EMBO J. 2020 Apr 15;39(8):e104246. doi: 10.15252/embj.2019104246. EMBO J. 2020. PMID: 32291792 Free PMC article. No abstract available.
2,497 results