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Prospective derivation of a living organoid biobank of colorectal cancer patients.
van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, van Houdt W, van Gorp J, Taylor-Weiner A, Kester L, McLaren-Douglas A, Blokker J, Jaksani S, Bartfeld S, Volckman R, van Sluis P, Li VS, Seepo S, Sekhar Pedamallu C, Cibulskis K, Carter SL, McKenna A, Lawrence MS, Lichtenstein L, Stewart C, Koster J, Versteeg R, van Oudenaarden A, Saez-Rodriguez J, Vries RG, Getz G, Wessels L, Stratton MR, McDermott U, Meyerson M, Garnett MJ, Clevers H. van de Wetering M, et al. Among authors: francies he. Cell. 2015 May 7;161(4):933-45. doi: 10.1016/j.cell.2015.03.053. Cell. 2015. PMID: 25957691 Free PMC article.
Drug Sensitivity Assays of Human Cancer Organoid Cultures.
Francies HE, Barthorpe A, McLaren-Douglas A, Barendt WJ, Garnett MJ. Francies HE, et al. Methods Mol Biol. 2019;1576:339-351. doi: 10.1007/7651_2016_10. Methods Mol Biol. 2019. PMID: 27628132 Free PMC article.
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M. Broutier L, et al. Among authors: francies he. Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13. Nat Med. 2017. PMID: 29131160 Free PMC article.
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J, Vermeulen L, Hazelwood L, Francies H, Garnett MJ, Winton DJ. Buczacki SJA, et al. J Exp Med. 2018 Jul 2;215(7):1891-1912. doi: 10.1084/jem.20171385. Epub 2018 May 31. J Exp Med. 2018. PMID: 29853607 Free PMC article.
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Li X, Francies HE, Secrier M, Perner J, Miremadi A, Galeano-Dalmau N, Barendt WJ, Letchford L, Leyden GM, Goffin EK, Barthorpe A, Lightfoot H, Chen E, Gilbert J, Noorani A, Devonshire G, Bower L, Grantham A, MacRae S, Grehan N, Wedge DC, Fitzgerald RC, Garnett MJ. Li X, et al. Among authors: francies he. Nat Commun. 2018 Jul 30;9(1):2983. doi: 10.1038/s41467-018-05190-9. Nat Commun. 2018. PMID: 30061675 Free PMC article.
Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.
Driehuis E, van Hoeck A, Moore K, Kolders S, Francies HE, Gulersonmez MC, Stigter ECA, Burgering B, Geurts V, Gracanin A, Bounova G, Morsink FH, Vries R, Boj S, van Es J, Offerhaus GJA, Kranenburg O, Garnett MJ, Wessels L, Cuppen E, Brosens LAA, Clevers H. Driehuis E, et al. Among authors: francies he. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26580-26590. doi: 10.1073/pnas.1911273116. Epub 2019 Dec 9. Proc Natl Acad Sci U S A. 2019. PMID: 31818951 Free PMC article.
CELLector: Genomics-Guided Selection of Cancer In Vitro Models.
Najgebauer H, Yang M, Francies HE, Pacini C, Stronach EA, Garnett MJ, Saez-Rodriguez J, Iorio F. Najgebauer H, et al. Among authors: francies he. Cell Syst. 2020 May 20;10(5):424-432.e6. doi: 10.1016/j.cels.2020.04.007. Cell Syst. 2020. PMID: 32437684 Free article.
22 results