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TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration.
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Galati A, Palumbo V, Kobin MA, Tartaglia GG, Colantoni A, Proietti G, Wu Y, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD. Chen L, et al. Among authors: francia s. Nucleic Acids Res. 2022 Nov 28;50(21):12400-12424. doi: 10.1093/nar/gkac659. Nucleic Acids Res. 2022. PMID: 35947650 Free PMC article.
DNA Damage Triggers a New Phase in Neurodegeneration.
Pessina F, Gioia U, Brandi O, Farina S, Ceccon M, Francia S, d'Adda di Fagagna F. Pessina F, et al. Among authors: francia s. Trends Genet. 2021 Apr;37(4):337-354. doi: 10.1016/j.tig.2020.09.006. Epub 2020 Oct 2. Trends Genet. 2021. PMID: 33020022 Free article. Review.
A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks.
Iannelli F, Galbiati A, Capozzo I, Nguyen Q, Magnuson B, Michelini F, D'Alessandro G, Cabrini M, Roncador M, Francia S, Crosetto N, Ljungman M, Carninci P, d'Adda di Fagagna F. Iannelli F, et al. Among authors: francia s. Nat Commun. 2017 May 31;8:15656. doi: 10.1038/ncomms15656. Nat Commun. 2017. PMID: 28561034 Free PMC article.
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, Cabrini M, Wang Y, Capozzo I, Iannelli F, Matti V, Francia S, Shivashankar GV, Walter NG, d'Adda di Fagagna F. Michelini F, et al. Among authors: francia s. Nat Cell Biol. 2017 Dec;19(12):1400-1411. doi: 10.1038/ncb3643. Epub 2017 Nov 27. Nat Cell Biol. 2017. PMID: 29180822 Free PMC article.
95 results