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CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness.
Mutascio S, Mota T, Franchitti L, Sharma AA, Willemse A, Bergstresser SN, Wang H, Statzu M, Tharp GK, Weiler J, Sékaly RP, Bosinger SE, Paiardini M, Silvestri G, Jones RB, Kulpa DA. Mutascio S, et al. Among authors: franchitti l. Immunity. 2023 May 9;56(5):1132-1147.e6. doi: 10.1016/j.immuni.2023.03.010. Epub 2023 Apr 7. Immunity. 2023. PMID: 37030290 Free PMC article.
CD8+ lymphocytes do not impact SIV reservoir establishment under ART.
Statzu M, Jin W, Fray EJ, Wong AKH, Kumar MR, Ferrer E, Docken SS, Pinkevych M, McBrien JB, Fennessey CM, Keele BF, Liang S, Harper JL, Mutascio S, Franchitti L, Wang H, Cicetti D, Bosinger SE, Carnathan DG, Vanderford TH, Margolis DM, Garcia-Martinez JV, Chahroudi A, Paiardini M, Siliciano J, Davenport MP, Kulpa DA, Siliciano RS, Silvestri G. Statzu M, et al. Among authors: franchitti l. Nat Microbiol. 2023 Feb;8(2):299-308. doi: 10.1038/s41564-022-01311-9. Epub 2023 Jan 23. Nat Microbiol. 2023. PMID: 36690860 Free PMC article.
The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence.
Strongin Z, Hoang TN, Tharp GK, Rahmberg AR, Harper JL, Nguyen K, Franchitti L, Cervasi B, Lee M, Zhang Z, Boritz EA, Silvestri G, Marconi VC, Bosinger SE, Brenchley JM, Kulpa DA, Paiardini M. Strongin Z, et al. Among authors: franchitti l. PLoS Pathog. 2022 Jul 22;18(7):e1010723. doi: 10.1371/journal.ppat.1010723. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35867722 Free PMC article.
Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
McBrien JB, Mavigner M, Franchitti L, Smith SA, White E, Tharp GK, Walum H, Busman-Sahay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G. McBrien JB, et al. Among authors: franchitti l. Nature. 2020 Feb;578(7796):E21. doi: 10.1038/s41586-020-2002-9. Nature. 2020. PMID: 32015546
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.
McBrien JB, Mavigner M, Franchitti L, Smith SA, White E, Tharp GK, Walum H, Busman-Sahay K, Aguilera-Sandoval CR, Thayer WO, Spagnuolo RA, Kovarova M, Wahl A, Cervasi B, Margolis DM, Vanderford TH, Carnathan DG, Paiardini M, Lifson JD, Lee JH, Safrit JT, Bosinger SE, Estes JD, Derdeyn CA, Garcia JV, Kulpa DA, Chahroudi A, Silvestri G. McBrien JB, et al. Among authors: franchitti l. Nature. 2020 Feb;578(7793):154-159. doi: 10.1038/s41586-020-1946-0. Epub 2020 Jan 22. Nature. 2020. PMID: 31969705 Free PMC article.
Fine tuning of the DNAM-1/TIGIT/ligand axis in mucosal T cells and its dysregulation in pediatric inflammatory bowel diseases (IBD).
Battella S, Oliva S, Franchitti L, La Scaleia R, Soriani A, Isoldi S, Capuano C, Pighi C, Morrone S, Galandrini R, Santoni A, Palmieri G. Battella S, et al. Among authors: franchitti l. Mucosal Immunol. 2019 Nov;12(6):1358-1369. doi: 10.1038/s41385-019-0208-7. Epub 2019 Oct 3. Mucosal Immunol. 2019. PMID: 31582819 Free article.
Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy.
Battella S, Cox MC, La Scaleia R, Di Napoli A, Di Landro F, Porzia A, Franchitti L, Mainiero F, Ruco L, Monarca B, Santoni A, Palmieri G. Battella S, et al. Among authors: franchitti l. Cancer Immunol Immunother. 2017 Oct;66(10):1295-1306. doi: 10.1007/s00262-017-2026-7. Epub 2017 May 29. Cancer Immunol Immunother. 2017. PMID: 28555258 Free PMC article.