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Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain.
Gualdani R, Ceruti S, Magni G, Merli D, Di Cesare Mannelli L, Francesconi O, Richichi B, la Marca G, Ghelardini C, Moncelli MR, Nativi C. Gualdani R, et al. Among authors: francesconi o. ACS Chem Neurosci. 2015 Mar 18;6(3):380-5. doi: 10.1021/cn500248u. Epub 2015 Jan 6. ACS Chem Neurosci. 2015. PMID: 25546551
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain.
Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S. Nativi C, et al. Among authors: francesconi o. Sci Rep. 2013;3:2005. doi: 10.1038/srep02005. Sci Rep. 2013. PMID: 23774285 Free PMC article.
Synthetic aminopyrrolic receptors have apoptosis inducing activity.
Park SH, Choi YP, Park J, Share A, Francesconi O, Nativi C, Namkung W, Sessler JL, Roelens S, Shin I. Park SH, et al. Among authors: francesconi o. Chem Sci. 2015 Dec 1;6(12):7284-7292. doi: 10.1039/c5sc03200h. Epub 2015 Oct 2. Chem Sci. 2015. PMID: 28757987 Free PMC article.
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).
Fragai M, Comito G, Di Cesare Mannelli L, Gualdani R, Calderone V, Louka A, Richichi B, Francesconi O, Angeli A, Nocentini A, Gratteri P, Chiarugi P, Ghelardini C, Tadini-Buoninsegni F, Supuran CT, Nativi C. Fragai M, et al. Among authors: francesconi o. J Med Chem. 2017 Nov 9;60(21):9003-9011. doi: 10.1021/acs.jmedchem.7b01237. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29048889
43 results