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EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.
Porru M, Zizza P, Franceschin M, Leonetti C, Biroccio A. Porru M, et al. Among authors: franceschin m. Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1362-1370. doi: 10.1016/j.bbagen.2016.11.010. Epub 2016 Nov 9. Biochim Biophys Acta Gen Subj. 2017. PMID: 27838395 Review.
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, Biroccio A. Casagrande V, et al. Among authors: franceschin m. J Med Chem. 2011 Mar 10;54(5):1140-56. doi: 10.1021/jm1013665. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280624
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.
Biroccio A, Porru M, Rizzo A, Salvati E, D'Angelo C, Orlandi A, Passeri D, Franceschin M, Stevens MF, Gilson E, Beretta G, Zupi G, Pisano C, Zunino F, Leonetti C. Biroccio A, et al. Among authors: franceschin m. Clin Cancer Res. 2011 Apr 15;17(8):2227-36. doi: 10.1158/1078-0432.CCR-10-3033. Epub 2011 Feb 25. Clin Cancer Res. 2011. PMID: 21355072
Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.
Franceschin M, Rizzo A, Casagrande V, Salvati E, Alvino A, Altieri A, Ciammaichella A, Iachettini S, Leonetti C, Ortaggi G, Porru M, Bianco A, Biroccio A. Franceschin M, et al. ChemMedChem. 2012 Dec;7(12):2144-54. doi: 10.1002/cmdc.201200348. Epub 2012 Oct 24. ChemMedChem. 2012. PMID: 23097341
Natural and synthetic G-quadruplex interactive berberine derivatives.
Franceschin M, Rossetti L, D'Ambrosio A, Schirripa S, Bianco A, Ortaggi G, Savino M, Schultes C, Neidle S. Franceschin M, et al. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1707-11. doi: 10.1016/j.bmcl.2005.12.001. Epub 2006 Jan 11. Bioorg Med Chem Lett. 2006. PMID: 16377184
36 results