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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
Murray A, Gough G, Cindrić A, Vučković F, Koschut D, Borelli V, Petrović DJ, Bekavac A, Plećaš A, Hribljan V, Brunmeir R, Jurić J, Pučić-Baković M, Slana A, Deriš H, Frkatović A, Groet J, O'Brien NL, Chen HY, Yeap YJ, Delom F, Havlicek S, Gammon L, Hamburg S, Startin C, D'Souza H, Mitrečić D, Kero M, Odak L, Krušlin B, Krsnik Ž, Kostović I, Foo JN, Loh YH, Dunn NR, de la Luna S, Spector T, Barišić I, Thomas MSC, Strydom A, Franceschi C, Lauc G, Krištić J, Alić I, Nižetić D. Murray A, et al. Among authors: franceschi c. EBioMedicine. 2023 Aug;94:104692. doi: 10.1016/j.ebiom.2023.104692. Epub 2023 Jul 12. EBioMedicine. 2023. PMID: 37451904 Free PMC article.
Small immunological clocks identified by deep learning and gradient boosting.
Kalyakulina A, Yusipov I, Kondakova E, Bacalini MG, Franceschi C, Vedunova M, Ivanchenko M. Kalyakulina A, et al. Among authors: franceschi c. Front Immunol. 2023 Aug 25;14:1177611. doi: 10.3389/fimmu.2023.1177611. eCollection 2023. Front Immunol. 2023. PMID: 37691946 Free PMC article.
Epigenetics of the far northern Yakutian population.
Kalyakulina A, Yusipov I, Kondakova E, Bacalini MG, Giuliani C, Sivtseva T, Semenov S, Ksenofontov A, Nikolaeva M, Khusnutdinova E, Zakharova R, Vedunova M, Franceschi C, Ivanchenko M. Kalyakulina A, et al. Among authors: franceschi c. Clin Epigenetics. 2023 Dec 6;15(1):189. doi: 10.1186/s13148-023-01600-y. Clin Epigenetics. 2023. PMID: 38053163 Free PMC article.
Where are we in the implementation of tissue-specific epigenetic clocks?
Sala C, Di Lena P, Fernandes Durso D, Faria do Valle I, Bacalini MG, Dall'Olio D, Franceschi C, Castellani G, Garagnani P, Nardini C. Sala C, et al. Among authors: franceschi c. Front Bioinform. 2024 Mar 4;4:1306244. doi: 10.3389/fbinf.2024.1306244. eCollection 2024. Front Bioinform. 2024. PMID: 38501111 Free PMC article.
eXplainable Artificial Intelligence (XAI) in aging clock models.
Kalyakulina A, Yusipov I, Moskalev A, Franceschi C, Ivanchenko M. Kalyakulina A, et al. Among authors: franceschi c. Ageing Res Rev. 2024 Jan;93:102144. doi: 10.1016/j.arr.2023.102144. Epub 2023 Nov 28. Ageing Res Rev. 2024. PMID: 38030090 Review.
Organ-specific biological clocks: Ageotyping for personalized anti-aging medicine.
Prattichizzo F, Frigé C, Pellegrini V, Scisciola L, Santoro A, Monti D, Rippo MR, Ivanchenko M, Olivieri F, Franceschi C. Prattichizzo F, et al. Among authors: franceschi c. Ageing Res Rev. 2024 Apr;96:102253. doi: 10.1016/j.arr.2024.102253. Epub 2024 Mar 4. Ageing Res Rev. 2024. PMID: 38447609 Review.
Dementia, infections and vaccines: 30 years of controversy.
Ecarnot F, Boccardi V, Calcagno A, Franceschi C, Fülop T, Itzhaki RF, Michel JP, Panza F, Rainero I, Solfrizzi V, Ticinesi A, Veronese N, Maggi S. Ecarnot F, et al. Among authors: franceschi c. Aging Clin Exp Res. 2023 Jun;35(6):1145-1160. doi: 10.1007/s40520-023-02409-8. Epub 2023 May 9. Aging Clin Exp Res. 2023. PMID: 37160649 Free PMC article. Review.
The expression pattern of GDF15 in human brain changes during aging and in Alzheimer's disease.
Chiariello A, Valente S, Pasquinelli G, Baracca A, Sgarbi G, Solaini G, Medici V, Fantini V, Poloni TE, Tognocchi M, Arcaro M, Galimberti D, Franceschi C, Capri M, Salvioli S, Conte M. Chiariello A, et al. Among authors: franceschi c. Front Aging Neurosci. 2023 Jan 9;14:1058665. doi: 10.3389/fnagi.2022.1058665. eCollection 2022. Front Aging Neurosci. 2023. PMID: 36698863 Free PMC article.
1,018 results