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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.
Galvan L, Francelle L, Gaillard MC, de Longprez L, Carrillo-de Sauvage MA, Liot G, Cambon K, Stimmer L, Luccantoni S, Flament J, Valette J, de Chaldée M, Auregan G, Guillermier M, Joséphine C, Petit F, Jan C, Jarrige M, Dufour N, Bonvento G, Humbert S, Saudou F, Hantraye P, Merienne K, Bemelmans AP, Perrier AL, Déglon N, Brouillet E. Galvan L, et al. Among authors: francelle l. Brain. 2018 May 1;141(5):1434-1454. doi: 10.1093/brain/awy057. Brain. 2018. PMID: 29534157 Free PMC article.
Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
Francelle L, Galvan L, Gaillard MC, Guillermier M, Houitte D, Bonvento G, Petit F, Jan C, Dufour N, Hantraye P, Elalouf JM, De Chaldée M, Déglon N, Brouillet E. Francelle L, et al. Hum Mol Genet. 2015 Mar 15;24(6):1563-73. doi: 10.1093/hmg/ddu571. Epub 2014 Nov 14. Hum Mol Genet. 2015. PMID: 25398949 Free PMC article.
High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.
Charbord J, Poydenot P, Bonnefond C, Feyeux M, Casagrande F, Brinon B, Francelle L, Aurégan G, Guillermier M, Cailleret M, Viegas P, Nicoleau C, Martinat C, Brouillet E, Cattaneo E, Peschanski M, Lechuga M, Perrier AL. Charbord J, et al. Among authors: francelle l. Stem Cells. 2013 Sep;31(9):1816-28. doi: 10.1002/stem.1430. Stem Cells. 2013. PMID: 23712629
Contribution of Neuroepigenetics to Huntington's Disease.
Francelle L, Lotz C, Outeiro T, Brouillet E, Merienne K. Francelle L, et al. Front Hum Neurosci. 2017 Jan 30;11:17. doi: 10.3389/fnhum.2017.00017. eCollection 2017. Front Hum Neurosci. 2017. PMID: 28194101 Free PMC article. Review.
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF. Blum D, et al. Among authors: francelle l. Hum Mol Genet. 2015 Jan 1;24(1):76-85. doi: 10.1093/hmg/ddu421. Epub 2014 Aug 20. Hum Mol Genet. 2015. PMID: 25143394
17 results