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The intrinsic substrate specificity of the human tyrosine kinome.
Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Yaron-Barir TM, et al. Among authors: frame mc. Nature. 2024 May 8. doi: 10.1038/s41586-024-07407-y. Online ahead of print. Nature. 2024. PMID: 38720073
Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.
Li Mow Chee F, Beernaert B, Griffith BGC, Loftus AEP, Kumar Y, Wills JC, Lee M, Valli J, Wheeler AP, Armstrong JD, Parsons M, Leigh IM, Proby CM, von Kriegsheim A, Bickmore WA, Frame MC, Byron A. Li Mow Chee F, et al. Among authors: frame mc. Nat Commun. 2023 Mar 23;14(1):1602. doi: 10.1038/s41467-023-37021-x. Nat Commun. 2023. PMID: 36959177 Free PMC article.
Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer.
Millar FR, Pennycuick A, Muir M, Quintanilla A, Hari P, Freyer E, Gautier P, Meynert A, Grimes G, Coll CS, Zdral S, Victorelli S, Teixeira VH, Connelly J, Passos JF, Ros MA, Wallace WAH, Frame MC, Sims AH, Boulter L, Janes SM, Wilkinson S, Acosta JC. Millar FR, et al. Among authors: frame mc. Cell Rep. 2022 Nov 8;41(6):111596. doi: 10.1016/j.celrep.2022.111596. Cell Rep. 2022. PMID: 36351380 Free PMC article.
Characterisation of a nucleo-adhesome.
Byron A, Griffith BGC, Herrero A, Loftus AEP, Koeleman ES, Kogerman L, Dawson JC, McGivern N, Culley J, Grimes GR, Serrels B, von Kriegsheim A, Brunton VG, Frame MC. Byron A, et al. Among authors: frame mc. Nat Commun. 2022 Jun 1;13(1):3053. doi: 10.1038/s41467-022-30556-5. Nat Commun. 2022. PMID: 35650196 Free PMC article.
A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Temps C, Lietha D, Webb ER, Li XF, Dawson JC, Muir M, Macleod KG, Valero T, Munro AF, Contreras-Montoya R, Luque-Ortega JR, Fraser C, Beetham H, Schoenherr C, Lopalco M, Arends MJ, Frame MC, Qian BZ, Brunton VG, Carragher NO, Unciti-Broceta A. Temps C, et al. Among authors: frame mc. Cancer Res. 2021 Nov 1;81(21):5438-5450. doi: 10.1158/0008-5472.CAN-21-0613. Epub 2021 Aug 20. Cancer Res. 2021. PMID: 34417202 Free PMC article.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium; van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Leach JDG, et al. Among authors: frame mc. Nat Commun. 2021 Jun 8;12(1):3464. doi: 10.1038/s41467-021-23717-5. Nat Commun. 2021. PMID: 34103493 Free PMC article.
160 results