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The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann AC, Price RN, Wirjanata G, Noviyanti R, Tumwebaze P, Cooper RA, Rosenthal PJ, Sanz LM, Gamo FJ, Joseph J, Singh S, Bashyam S, Augereau JM, Giraud E, Bozec T, Vermat T, Tuffal G, Guillon JM, Menegotto J, Sallé L, Louit G, Cabanis MJ, Nicolas MF, Doubovetzky M, Merino R, Bessila N, Angulo-Barturen I, Baud D, Bebrevska L, Escudié F, Niles JC, Blasco B, Campbell S, Courtemanche G, Fraisse L, Pellet A, Fidock DA, Leroy D. Murithi JM, et al. Among authors: fraisse l. Sci Transl Med. 2021 Jul 21;13(603):eabg6013. doi: 10.1126/scitranslmed.abg6013. Sci Transl Med. 2021. PMID: 34290058 Free PMC article.
Selection of a trioxaquine as an antimalarial drug candidate.
Coslédan F, Fraisse L, Pellet A, Guillou F, Mordmüller B, Kremsner PG, Moreno A, Mazier D, Maffrand JP, Meunier B. Coslédan F, et al. Among authors: fraisse l. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17579-84. doi: 10.1073/pnas.0804338105. Epub 2008 Nov 5. Proc Natl Acad Sci U S A. 2008. PMID: 18987321 Free PMC article.
In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.
Daher W, Pelinski L, Klieber S, Sadoun F, Meunier V, Bourrié M, Biot C, Guillou F, Fabre G, Brocard J, Fraisse L, Maffrand JP, Khalife J, Dive D. Daher W, et al. Among authors: fraisse l. Drug Metab Dispos. 2006 Apr;34(4):667-82. doi: 10.1124/dmd.104.003202. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415117
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins.
Kling A, Lukat P, Almeida DV, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel SC, König C, Ammerman NC, Barrio MB, Borchers K, Bordon-Pallier F, Brönstrup M, Courtemanche G, Gerlitz M, Geslin M, Hammann P, Heinz DW, Hoffmann H, Klieber S, Kohlmann M, Kurz M, Lair C, Matter H, Nuermberger E, Tyagi S, Fraisse L, Grosset JH, Lagrange S, Müller R. Kling A, et al. Among authors: fraisse l. Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690. Science. 2015. PMID: 26045430
A chemical proteomics approach for the search of pharmacological targets of the antimalarial clinical candidate albitiazolium in Plasmodium falciparum using photocrosslinking and click chemistry.
Penarete-Vargas DM, Boisson A, Urbach S, Chantelauze H, Peyrottes S, Fraisse L, Vial HJ. Penarete-Vargas DM, et al. Among authors: fraisse l. PLoS One. 2014 Dec 3;9(12):e113918. doi: 10.1371/journal.pone.0113918. eCollection 2014. PLoS One. 2014. PMID: 25470252 Free PMC article.
Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2.
Driouich JS, Cochin M, Touret F, Petit PR, Gilles M, Moureau G, Barthélémy K, Laprie C, Wattanakul T, Chotsiri P, Hoglund RM, Tarning J, Fraisse L, Sjö P, Mowbray CE, Escudié F, Scandale I, Chatelain E, de Lamballerie X, Solas C, Nougairède A. Driouich JS, et al. Among authors: fraisse l. EBioMedicine. 2022 Aug;82:104148. doi: 10.1016/j.ebiom.2022.104148. Epub 2022 Jul 11. EBioMedicine. 2022. PMID: 35834886 Free PMC article.
Safety biomarkers for development of vaccines and biologics: Report from the safety biomarkers symposium held on November 28-29, 2017, Marcy l'Etoile, France.
Doubovetzky M, Ataman-Önal Y, Chousterman B, Feroldi E, Garçon N, Grillet MH, Kramer D, Laurent S, Lewis DJM, Luna E, Manigold T, Syntin P, Burdin N, Fraisse L, Jackson N. Doubovetzky M, et al. Among authors: fraisse l. Vaccine. 2020 Dec 3;38(51):8055-8063. doi: 10.1016/j.vaccine.2020.10.015. Epub 2020 Nov 10. Vaccine. 2020. PMID: 33187767
Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate.
Wein S, Maynadier M, Bordat Y, Perez J, Maheshwari S, Bette-Bobillo P, Tran Van Ba C, Penarete-Vargas D, Fraisse L, Cerdan R, Vial H. Wein S, et al. Among authors: fraisse l. Br J Pharmacol. 2012 Aug;166(8):2263-76. doi: 10.1111/j.1476-5381.2012.01966.x. Br J Pharmacol. 2012. PMID: 22471905 Free PMC article.
45 results