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Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.
da Silva Cunha TT, Silva RR, Rodrigues DA, de Sena Murteira Pinheiro P, Kronenberger T, Sant'Anna CMR, Noël F, Fraga CAM. da Silva Cunha TT, et al. Among authors: fraga cam. Biomolecules. 2022 Aug 12;12(8):1112. doi: 10.3390/biom12081112. Biomolecules. 2022. PMID: 36009006 Free PMC article.
An Unusual Intramolecular Halogen Bond Guides Conformational Selection.
Tesch R, Becker C, Müller MP, Beck ME, Quambusch L, Getlik M, Lategahn J, Uhlenbrock N, Costa FN, Polêto MD, Pinheiro PSM, Rodrigues DA, Sant'Anna CMR, Ferreira FF, Verli H, Fraga CAM, Rauh D. Tesch R, et al. Among authors: fraga cam. Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9970-9975. doi: 10.1002/anie.201804917. Epub 2018 Jul 9. Angew Chem Int Ed Engl. 2018. PMID: 29873877
Molecular hybridization: a powerful tool for multitarget drug discovery.
de Sena Murteira Pinheiro P, Franco LS, Montagnoli TL, Fraga CAM. de Sena Murteira Pinheiro P, et al. Among authors: fraga cam. Expert Opin Drug Discov. 2024 Apr;19(4):451-470. doi: 10.1080/17460441.2024.2322990. Epub 2024 Mar 8. Expert Opin Drug Discov. 2024. PMID: 38456452 Review.
Synthesis and analgesic profile of conformationally constrained N-acylhydrazone analogues: discovery of novel N-arylideneamino quinazolin-4(3H)-one compounds derived from natural safrole.
Maia RC, Silva LL, Mazzeu EF, Fumian MM, de Rezende CM, Doriguetto AC, Corrêa RS, Miranda AL, Barreiro EJ, Fraga CA. Maia RC, et al. Bioorg Med Chem. 2009 Sep 15;17(18):6517-25. doi: 10.1016/j.bmc.2009.08.009. Epub 2009 Aug 9. Bioorg Med Chem. 2009. PMID: 19699644 Free article.
151 results