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Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
Fathalla RK, Fröhner W, Bader CD, Fischer PD, Dahlem C, Chatterjee D, Mathea S, Kiemer AK, Arthanari H, Müller R, Abdel-Halim M, Ducho C, Engel M. Fathalla RK, et al. Among authors: frohner w. J Med Chem. 2022 Nov 10;65(21):14740-14763. doi: 10.1021/acs.jmedchem.2c01275. Epub 2022 Oct 21. J Med Chem. 2022. PMID: 36269107 Free PMC article.
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Fröhner W, Hartmann RW, Biondi RM, Engel M. Stroba A, et al. Among authors: frohner w. J Med Chem. 2009 Aug 13;52(15):4683-93. doi: 10.1021/jm9001499. J Med Chem. 2009. PMID: 19606904
An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.
Arencibia JM, Fröhner W, Krupa M, Pastor-Flores D, Merker P, Oellerich T, Neimanis S, Schmithals C, Köberle V, Süß E, Zeuzem S, Stark H, Piiper A, Odadzic D, Schulze JO, Biondi RM. Arencibia JM, et al. Among authors: frohner w. ACS Chem Biol. 2017 Feb 17;12(2):564-573. doi: 10.1021/acschembio.6b00827. Epub 2017 Jan 13. ACS Chem Biol. 2017. PMID: 28045490