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Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA.
J Med Chem. 2022 Nov 10;65(21):14740-14763. doi: 10.1021/acs.jmedchem.2c01275. Epub 2022 Oct 21.
J Med Chem. 2022.
PMID: 36269107
Free PMC article.
4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.
Fröhner W, Lopez-Garcia LA, Neimanis S, Weber N, Navratil J, Maurer F, Stroba A, Zhang H, Biondi RM, Engel M.
Fröhner W, et al.
J Med Chem. 2011 Oct 13;54(19):6714-23. doi: 10.1021/jm2005892. Epub 2011 Sep 14.
J Med Chem. 2011.
PMID: 21863889
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2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.
Wilhelm A, Lopez-Garcia LA, Busschots K, Fröhner W, Maurer F, Boettcher S, Zhang H, Schulze JO, Biondi RM, Engel M.
Wilhelm A, et al. Among authors: frohner w.
J Med Chem. 2012 Nov 26;55(22):9817-30. doi: 10.1021/jm3010477. Epub 2012 Nov 12.
J Med Chem. 2012.
PMID: 23106316
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3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.
Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Fröhner W, Hartmann RW, Biondi RM, Engel M.
Stroba A, et al. Among authors: frohner w.
J Med Chem. 2009 Aug 13;52(15):4683-93. doi: 10.1021/jm9001499.
J Med Chem. 2009.
PMID: 19606904
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Allosteric regulation of protein kinase PKCζ by the N-terminal C1 domain and small compounds to the PIF-pocket.
Lopez-Garcia LA, Schulze JO, Fröhner W, Zhang H, Süss E, Weber N, Navratil J, Amon S, Hindie V, Zeuzem S, Jørgensen TJ, Alzari PM, Neimanis S, Engel M, Biondi RM.
Lopez-Garcia LA, et al. Among authors: frohner w.
Chem Biol. 2011 Nov 23;18(11):1463-73. doi: 10.1016/j.chembiol.2011.08.010.
Chem Biol. 2011.
PMID: 22118680
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An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms.
Arencibia JM, Fröhner W, Krupa M, Pastor-Flores D, Merker P, Oellerich T, Neimanis S, Schmithals C, Köberle V, Süß E, Zeuzem S, Stark H, Piiper A, Odadzic D, Schulze JO, Biondi RM.
Arencibia JM, et al. Among authors: frohner w.
ACS Chem Biol. 2017 Feb 17;12(2):564-573. doi: 10.1021/acschembio.6b00827. Epub 2017 Jan 13.
ACS Chem Biol. 2017.
PMID: 28045490
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Synthesis and activity of carbazole derivatives against Mycobacterium tuberculosis.
Choi TA, Czerwonka R, Fröhner W, Krahl MP, Reddy KR, Franzblau SG, Knölker HJ.
Choi TA, et al. Among authors: frohner w.
ChemMedChem. 2006 Aug;1(8):812-5. doi: 10.1002/cmdc.200600002.
ChemMedChem. 2006.
PMID: 16902934
No abstract available.
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Regiospecific synthesis of mono-N-substituted indolopyrrolocarbazoles.
Fröhner W, Monse B, Braxmeier TM, Casiraghi L, Sahagún H, Seneci P.
Fröhner W, et al.
Org Lett. 2005 Oct 13;7(21):4573-6. doi: 10.1021/ol051550a.
Org Lett. 2005.
PMID: 16209482
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