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Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major.
Iwasaki J, Lorimer DD, Vivoli-Vega M, Kibble EA, Peacock CS, Abendroth J, Mayclin SJ, Dranow DM, Pierce PG, Fox D, Lewis M, Bzdyl NM, Kristensen SS, Inglis TJJ, Kahler CM, Bond CS, Hasenkopf A, Seufert F, Schmitz J, Marshall LE, Scott AE, Norville IH, Myler PJ, Holzgrabe U, Harmer NJ, Sarkar-Tyson M. Iwasaki J, et al. Among authors: fox d. J Antimicrob Chemother. 2022 May 29;77(6):1625-1634. doi: 10.1093/jac/dkac065. J Antimicrob Chemother. 2022. PMID: 35245364 Free PMC article.
A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD. Begley DW, et al. Among authors: fox d 3rd. Antimicrob Agents Chemother. 2014;58(3):1458-67. doi: 10.1128/AAC.01875-13. Epub 2013 Dec 23. Antimicrob Agents Chemother. 2014. PMID: 24366729 Free PMC article.
Combining functional and structural genomics to sample the essential Burkholderia structome.
Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D 3rd, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC. Baugh L, et al. Among authors: fox d 3rd. PLoS One. 2013;8(1):e53851. doi: 10.1371/journal.pone.0053851. Epub 2013 Jan 31. PLoS One. 2013. PMID: 23382856 Free PMC article.
Increasing the structural coverage of tuberculosis drug targets.
Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ. Baugh L, et al. Among authors: fox d 3rd. Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003. Epub 2014 Dec 19. Tuberculosis (Edinb). 2015. PMID: 25613812 Free PMC article.
Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.
Hall A, Abendroth J, Bolejack MJ, Ceska T, Dell'Aiera S, Ellis V, Fox D 3rd, François C, Muruthi MM, Prével C, Poullennec K, Romanov S, Valade A, Vanbellinghen A, Yano J, Geraerts M. Hall A, et al. Among authors: fox d 3rd. ACS Med Chem Lett. 2022 Jun 25;13(7):1099-1108. doi: 10.1021/acsmedchemlett.2c00134. eCollection 2022 Jul 14. ACS Med Chem Lett. 2022. PMID: 35859861 Free PMC article.
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
Juvvadi PR, Fox D 3rd, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Juvvadi PR, et al. Among authors: fox d 3rd. Nat Commun. 2019 Sep 19;10(1):4275. doi: 10.1038/s41467-019-12199-1. Nat Commun. 2019. PMID: 31537789 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35556558
Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Hagen TJ, Mo X, Burgin AB, Fox D 3rd, Zhang Z, Gurney ME. Hagen TJ, et al. Among authors: fox d 3rd. Bioorg Med Chem Lett. 2014 Aug 15;24(16):4031-4. doi: 10.1016/j.bmcl.2014.06.002. Epub 2014 Jun 12. Bioorg Med Chem Lett. 2014. PMID: 24998378 Free PMC article.
1,832 results