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Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling.
Canfrán-Duque A, Rotllan N, Zhang X, Andrés-Blasco I, Thompson BM, Sun J, Price NL, Fernández-Fuertes M, Fowler JW, Gómez-Coronado D, Sessa WC, Giannarelli C, Schneider RJ, Tellides G, McDonald JG, Fernández-Hernando C, Suárez Y. Canfrán-Duque A, et al. Among authors: fowler jw. Circulation. 2023 Jan 31;147(5):388-408. doi: 10.1161/CIRCULATIONAHA.122.059062. Epub 2022 Nov 23. Circulation. 2023. PMID: 36416142 Free PMC article.
Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.
Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Kraehling JR, et al. Among authors: fowler jw. Nat Commun. 2016 Nov 21;7:13516. doi: 10.1038/ncomms13516. Nat Commun. 2016. PMID: 27869117 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33453825
Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice.
Boutagy NE, Gamez-Mendez A, Fowler JW, Zhang H, Chaube BK, Esplugues E, Kuo A, Lee S, Horikami D, Zhang J, Citrin KM, Singh AK, Coon BG, Lee MY, Suarez Y, Fernandez-Hernando C, Sessa WC. Boutagy NE, et al. Among authors: fowler jw. J Clin Invest. 2024 Jan 4;134(4):e170453. doi: 10.1172/JCI170453. J Clin Invest. 2024. PMID: 38175710 Free PMC article.
Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma.
Singh AK, Chaube B, Citrin KM, Fowler JW, Lee S, Catarino J, Knight J, Lowery S, Shree S, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross TT, Malaker S, Suárez Y, Fernández-Hernando C, Grabinska K, Sessa WC. Singh AK, et al. Among authors: fowler jw. bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566870. doi: 10.1101/2023.11.13.566870. bioRxiv. 2023. PMID: 38014178 Free PMC article. Preprint.
TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes.
Boutagy NE, Fowler JW, Grabinska KA, Cardone R, Sun Q, Vazquez KR, Whalen MB, Zhu X, Chakraborty R, Martin KA, Simons M, Romanoski CE, Kibbey RG, Sessa WC. Boutagy NE, et al. Among authors: fowler jw. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2218150120. doi: 10.1073/pnas.2218150120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695914 Free PMC article.
80 results