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Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Colom B, Alcolea MP, Piedrafita G, Hall MWJ, Wabik A, Dentro SC, Fowler JC, Herms A, King C, Ong SH, Sood RK, Gerstung M, Martincorena I, Hall BA, Jones PH. Colom B, et al. Among authors: fowler jc. Nat Genet. 2020 Jun;52(6):604-614. doi: 10.1038/s41588-020-0624-3. Epub 2020 May 18. Nat Genet. 2020. PMID: 32424351 Free PMC article.
Somatic mutant clones colonize the human esophagus with age.
Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH. Martincorena I, et al. Among authors: fowler jc. Science. 2018 Nov 23;362(6417):911-917. doi: 10.1126/science.aau3879. Epub 2018 Oct 18. Science. 2018. PMID: 30337457 Free PMC article.
Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site.
Fowler JC, King C, Bryant C, Hall MWJ, Sood R, Ong SH, Earp E, Fernandez-Antoran D, Koeppel J, Dentro SC, Shorthouse D, Durrani A, Fife K, Rytina E, Milne D, Roshan A, Mahububani K, Saeb-Parsy K, Hall BA, Gerstung M, Jones PH. Fowler JC, et al. Cancer Discov. 2021 Feb;11(2):340-361. doi: 10.1158/2159-8290.CD-20-1092. Epub 2020 Oct 21. Cancer Discov. 2021. PMID: 33087317 Free PMC article.
Mutant clones in normal epithelium outcompete and eliminate emerging tumours.
Colom B, Herms A, Hall MWJ, Dentro SC, King C, Sood RK, Alcolea MP, Piedrafita G, Fernandez-Antoran D, Ong SH, Fowler JC, Mahbubani KT, Saeb-Parsy K, Gerstung M, Hall BA, Jones PH. Colom B, et al. Among authors: fowler jc. Nature. 2021 Oct;598(7881):510-514. doi: 10.1038/s41586-021-03965-7. Epub 2021 Oct 13. Nature. 2021. PMID: 34646013 Free PMC article.
Somatic mutations in facial skin from countries of contrasting skin cancer risk.
King C, Fowler JC, Abnizova I, Sood RK, Hall MWJ, Szeverényi I, Tham M, Huang J, Young SM, Hall BA, Birgitte Lane E, Jones PH. King C, et al. Among authors: fowler jc. Nat Genet. 2023 Sep;55(9):1440-1447. doi: 10.1038/s41588-023-01468-x. Epub 2023 Aug 3. Nat Genet. 2023. PMID: 37537257 Free PMC article.
197 results