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CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
Nature. 2022 Apr;604(7907):749-756. doi: 10.1038/s41586-022-04638-9. Epub 2022 Apr 20.
Nature. 2022.
PMID: 35444283
Free PMC article.
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
Szychowski J, Papp R, Dietrich E, Liu B, Vallée F, Leclaire ME, Fourtounis J, Martino G, Perryman AL, Pau V, Yin SY, Mader P, Roulston A, Truchon JF, Marshall CG, Diallo M, Duffy NM, Stocco R, Godbout C, Bonneau-Fortin A, Kryczka R, Bhaskaran V, Mao D, Orlicky S, Beaulieu P, Turcotte P, Kurinov I, Sicheri F, Mamane Y, Gallant M, Black WC.
Szychowski J, et al. Among authors: fourtounis j.
J Med Chem. 2022 Aug 11;65(15):10251-10284. doi: 10.1021/acs.jmedchem.2c00552. Epub 2022 Jul 26.
J Med Chem. 2022.
PMID: 35880755
Free PMC article.
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Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR.
Xu H, George E, Gallo D, Medvedev S, Wang X, Kryczka R, Hyer ML, Fourtounis J, Stocco R, Aguado-Fraile E, Petrone A, Yin SY, Shiwram A, Anderson M, Kim H, Liu F, Marshall CG, Simpkins F.
Xu H, et al. Among authors: fourtounis j.
Res Sq [Preprint]. 2024 Feb 16:rs.3.rs-3854682. doi: 10.21203/rs.3.rs-3854682/v1.
Res Sq. 2024.
PMID: 38410486
Free PMC article.
Preprint.
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Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene.
Fourtounis J, Wang IM, Mathieu MC, Claveau D, Loo T, Jackson AL, Peters MA, Therien AG, Boie Y, Crackower MA.
Fourtounis J, et al.
Respir Res. 2012 Oct 12;13(1):92. doi: 10.1186/1465-9921-13-92.
Respir Res. 2012.
PMID: 23061798
Free PMC article.
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Assessing protein-RNA interactions using microfluidic capillary mobility shift assays.
Fourtounis J, Falgueyret JP, Sayegh CE.
Fourtounis J, et al.
Anal Biochem. 2011 Apr 1;411(1):161-3. doi: 10.1016/j.ab.2010.11.042. Epub 2010 Dec 2.
Anal Biochem. 2011.
PMID: 21130065
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Immunohistochemical and biochemical assessment of caspase-3 activation and DNA fragmentation following transient focal ischemia in the rat.
Davoli MA, Fourtounis J, Tam J, Xanthoudakis S, Nicholson D, Robertson GS, Ng GY, Xu D.
Davoli MA, et al. Among authors: fourtounis j.
Neuroscience. 2002;115(1):125-36. doi: 10.1016/s0306-4522(02)00376-7.
Neuroscience. 2002.
PMID: 12401327
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Automated analysis of global ischemia-induced CA1 neuronal death using terminal UTP nick end labeling (TUNEL).
Davoli MA, Ren Y, Zhu Y, Fourtounis J, Jones C, Robertson GS, Ng GY, Xu D.
Davoli MA, et al. Among authors: fourtounis j.
J Neurosci Methods. 2002 Mar 30;115(1):55-61. doi: 10.1016/s0165-0270(01)00531-3.
J Neurosci Methods. 2002.
PMID: 11897363
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