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732 results

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SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer.
Xue Y, Meehan B, Fu Z, Wang XQD, Fiset PO, Rieker R, Levins C, Kong T, Zhu X, Morin G, Skerritt L, Herpel E, Venneti S, Martinez D, Judkins AR, Jung S, Camilleri-Broet S, Gonzalez AV, Guiot MC, Lockwood WW, Spicer JD, Agaimy A, Pastor WA, Dostie J, Rak J, Foulkes WD, Huang S. Xue Y, et al. Among authors: foulkes wd. Nat Commun. 2019 Feb 4;10(1):557. doi: 10.1038/s41467-019-08380-1. Nat Commun. 2019. PMID: 30718506 Free PMC article.
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
Witkowski L, Carrot-Zhang J, Albrecht S, Fahiminiya S, Hamel N, Tomiak E, Grynspan D, Saloustros E, Nadaf J, Rivera B, Gilpin C, Castellsagué E, Silva-Smith R, Plourde F, Wu M, Saskin A, Arseneault M, Karabakhtsian RG, Reilly EA, Ueland FR, Margiolaki A, Pavlakis K, Castellino SM, Lamovec J, Mackay HJ, Roth LM, Ulbright TM, Bender TA, Georgoulias V, Longy M, Berchuck A, Tischkowitz M, Nagel I, Siebert R, Stewart CJ, Arseneau J, McCluggage WG, Clarke BA, Riazalhosseini Y, Hasselblatt M, Majewski J, Foulkes WD. Witkowski L, et al. Among authors: foulkes wd. Nat Genet. 2014 May;46(5):438-43. doi: 10.1038/ng.2931. Epub 2014 Mar 23. Nat Genet. 2014. PMID: 24658002
Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.
Fahiminiya S, Witkowski L, Nadaf J, Carrot-Zhang J, Goudie C, Hasselblatt M, Johann P, Kool M, Lee RS, Gayden T, Roberts CW, Biegel JA, Jabado N, Majewski J, Foulkes WD. Fahiminiya S, et al. Among authors: foulkes wd. Oncotarget. 2016 Jan 12;7(2):1732-40. doi: 10.18632/oncotarget.6459. Oncotarget. 2016. PMID: 26646792 Free PMC article.
Loss of SMARCA4 (BRG1) protein expression as determined by immunohistochemistry in small-cell carcinoma of the ovary, hypercalcaemic type distinguishes these tumours from their mimics.
Clarke BA, Witkowski L, Ton Nu TN, Shaw PA, Gilks CB, Huntsman D, Karnezis AN, Sebire N, Lamovec J, Roth LM, Stewart CJ, Hasselblatt M, Foulkes WD, McCluggage WG. Clarke BA, et al. Among authors: foulkes wd. Histopathology. 2016 Nov;69(5):727-738. doi: 10.1111/his.12988. Epub 2016 Jul 28. Histopathology. 2016. PMID: 27100627
Hereditary SWI/SNF complex deficiency syndromes.
Agaimy A, Foulkes WD. Agaimy A, et al. Among authors: foulkes wd. Semin Diagn Pathol. 2018 May;35(3):193-198. doi: 10.1053/j.semdp.2018.01.002. Epub 2018 Feb 1. Semin Diagn Pathol. 2018. PMID: 29397238 Review.
Infantile Pulmonary Teratoid Tumor.
de Kock L, Fahiminiya S, Fiset PO, Astigarraga I, Nguyen VH, Albrecht S, Foulkes WD. de Kock L, et al. Among authors: foulkes wd. N Engl J Med. 2018 Jun 7;378(23):2238-2240. doi: 10.1056/NEJMc1803354. N Engl J Med. 2018. PMID: 29874541 No abstract available.
CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.
Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen H, Papadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD, Huang S. Xue Y, et al. Among authors: foulkes wd. Nat Commun. 2019 Feb 4;10(1):558. doi: 10.1038/s41467-018-06958-9. Nat Commun. 2019. PMID: 30718512 Free PMC article.
SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors.
Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M. Shorstova T, et al. Among authors: foulkes wd. Cancer Res. 2019 May 15;79(10):2761-2774. doi: 10.1158/0008-5472.CAN-18-1545. Epub 2019 Mar 15. Cancer Res. 2019. PMID: 30877105
732 results