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The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition).
Zhuang A, Yap FYT, Borg DJ, McCarthy D, Fotheringham A, Leung S, Penfold SA, Sourris KC, Coughlan MT, Schulz BL, Forbes JM. Zhuang A, et al. Among authors: fotheringham a. Endocrinol Diabetes Metab. 2021 Jun 22;4(3):e00278. doi: 10.1002/edm2.278. eCollection 2021 Jul. Endocrinol Diabetes Metab. 2021. PMID: 34277994 Free PMC article.
Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes.
Tesch G, Sourris KC, Summers SA, McCarthy D, Ward MS, Borg DJ, Gallo LA, Fotheringham AK, Pettit AR, Yap FY, Harcourt BE, Tan AL, Kausman JY, Nikolic-Paterson D, Kitching AR, Forbes JM. Tesch G, et al. Among authors: fotheringham ak. Diabetologia. 2014 Sep;57(9):1977-85. doi: 10.1007/s00125-014-3291-z. Epub 2014 Jun 24. Diabetologia. 2014. PMID: 24957662
Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice.
Gallo LA, Ward MS, Fotheringham AK, Zhuang A, Borg DJ, Flemming NB, Harvie BM, Kinneally TL, Yeh SM, McCarthy DA, Koepsell H, Vallon V, Pollock C, Panchapakesan U, Forbes JM. Gallo LA, et al. Among authors: fotheringham ak. Sci Rep. 2016 May 26;6:26428. doi: 10.1038/srep26428. Sci Rep. 2016. PMID: 27226136 Free PMC article.
Erratum: Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice.
Gallo LA, Ward MS, Fotheringham AK, Zhuang A, Borg DJ, Flemming NB, Harvie BM, Kinneally TL, Yeh SM, McCarthy DA, Koepsell H, Vallon V, Pollock C, Panchapakesan U, Forbes JM. Gallo LA, et al. Among authors: fotheringham ak. Sci Rep. 2016 Jul 7;6:28124. doi: 10.1038/srep28124. Sci Rep. 2016. PMID: 27389496 Free PMC article. No abstract available.
Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes.
Ward MS, Flemming NB, Gallo LA, Fotheringham AK, McCarthy DA, Zhuang A, Tang PH, Borg DJ, Shaw H, Harvie B, Briskey DR, Roberts LA, Plan MR, Murphy MP, Hodson MP, Forbes JM. Ward MS, et al. Among authors: fotheringham ak. Sci Rep. 2017 Nov 9;7(1):15190. doi: 10.1038/s41598-017-15589-x. Sci Rep. 2017. PMID: 29123192 Free PMC article.
Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction.
Borg DJ, Yap FYT, Keshvari S, Simmons DG, Gallo LA, Fotheringham AK, Zhuang A, Slattery RM, Hasnain SZ, Coughlan MT, Kantharidis P, Forbes JM. Borg DJ, et al. Among authors: fotheringham ak. Islets. 2018 Jan 2;10(1):10-24. doi: 10.1080/19382014.2017.1405189. Epub 2017 Dec 22. Islets. 2018. PMID: 29157116 Free PMC article.
Advanced glycation end products as predictors of renal function in youth with type 1 diabetes.
Forbes JM, Le Bagge S, Righi S, Fotheringham AK, Gallo LA, McCarthy DA, Leung S, Baskerville T, Nisbett J, Morton A, Teasdale S, D'Silva N, Barrett H, Jones T, Couper J, Donaghue K, Isbel N, Johnson DW, Donnellan L, Deo P, Akison LK, Moritz KM, O'Moore-Sullivan T. Forbes JM, et al. Among authors: fotheringham ak. Sci Rep. 2021 May 3;11(1):9422. doi: 10.1038/s41598-021-88786-4. Sci Rep. 2021. PMID: 33941808 Free PMC article.
47 results