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Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.
May CJ, Chesor M, Hunter SE, Hayes B, Barr R, Roberts T, Barrington FA, Farmer L, Ni L, Jackson M, Snethen H, Tavakolidakhrabadi N, Goldstone M, Gilbert R, Beesley M, Lennon R, Foster R, Coward R, Welsh GI, Saleem MA. May CJ, et al. Among authors: foster r. Kidney Int. 2023 Aug;104(2):265-278. doi: 10.1016/j.kint.2023.02.031. Epub 2023 Mar 20. Kidney Int. 2023. PMID: 36940798 Free article.
A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli.
Desideri S, Onions KL, Qiu Y, Ramnath RD, Butler MJ, Neal CR, King MLR, Salmon AE, Saleem MA, Welsh GI, Michel CC, Satchell SC, Salmon AHJ, Foster RR. Desideri S, et al. Among authors: foster rr. Kidney Int. 2018 May;93(5):1086-1097. doi: 10.1016/j.kint.2017.12.003. Epub 2018 Feb 9. Kidney Int. 2018. PMID: 29433915 Free PMC article.
Aldosterone induces albuminuria via matrix metalloproteinase-dependent damage of the endothelial glycocalyx.
Butler MJ, Ramnath R, Kadoya H, Desposito D, Riquier-Brison A, Ferguson JK, Onions KL, Ogier AS, ElHegni H, Coward RJ, Welsh GI, Foster RR, Peti-Peterdi J, Satchell SC. Butler MJ, et al. Among authors: foster rr. Kidney Int. 2019 Jan;95(1):94-107. doi: 10.1016/j.kint.2018.08.024. Epub 2018 Oct 31. Kidney Int. 2019. PMID: 30389198 Free PMC article.
Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease.
Ramnath RD, Butler MJ, Newman G, Desideri S, Russell A, Lay AC, Neal CR, Qiu Y, Fawaz S, Onions KL, Gamez M, Crompton M, Michie C, Finch N, Coward RJ, Welsh GI, Foster RR, Satchell SC. Ramnath RD, et al. Among authors: foster rr. Kidney Int. 2020 May;97(5):951-965. doi: 10.1016/j.kint.2019.09.035. Epub 2019 Nov 2. Kidney Int. 2020. PMID: 32037077 Free PMC article.
A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.
Kuzmuk V, Pranke I, Rollason R, Butler M, Ding WY, Beesley M, Waters AM, Coward RJ, Sessions R, Tuffin J, Foster RR, Mollet G, Antignac C, Edelman A, Welsh GI, Saleem MA. Kuzmuk V, et al. Among authors: foster rr. Kidney Int. 2024 Apr;105(4):744-758. doi: 10.1016/j.kint.2023.11.006. Epub 2023 Nov 22. Kidney Int. 2024. PMID: 37995908 Free article.
2,374 results