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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria.
Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT. Foss S, et al. Nat Commun. 2024 Mar 7;15(1):2007. doi: 10.1038/s41467-024-46321-9. Nat Commun. 2024. PMID: 38453922 Free PMC article.
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.
Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT. Grevys A, et al. Among authors: foss s. Nat Commun. 2018 Feb 12;9(1):621. doi: 10.1038/s41467-018-03061-x. Nat Commun. 2018. PMID: 29434196 Free PMC article.
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics.
Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT. Bern M, et al. Among authors: foss s. Sci Transl Med. 2020 Oct 14;12(565):eabb0580. doi: 10.1126/scitranslmed.abb0580. Sci Transl Med. 2020. PMID: 33055243
Antibody blockade of Jagged1 attenuates choroidal neovascularization.
Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E. Gjølberg TT, et al. Among authors: foss s. Nat Commun. 2023 May 30;14(1):3109. doi: 10.1038/s41467-023-38563-w. Nat Commun. 2023. PMID: 37253747 Free PMC article.
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life.
Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I. Andersen JT, et al. Among authors: foss s. J Biol Chem. 2012 Jun 29;287(27):22927-37. doi: 10.1074/jbc.M112.355131. Epub 2012 May 8. J Biol Chem. 2012. PMID: 22570488 Free PMC article.
Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells.
Lustig M, Chan C, Jansen JHM, Bräutigam M, Kölling MA, Gehlert CL, Baumann N, Mester S, Foss S, Andersen JT, Bastian L, Sondermann P, Peipp M, Burger R, Leusen JHW, Valerius T. Lustig M, et al. Among authors: foss s. Front Immunol. 2023 Jun 6;14:1178817. doi: 10.3389/fimmu.2023.1178817. eCollection 2023. Front Immunol. 2023. PMID: 37346044 Free PMC article.
105 results