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Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target.
Res Sq [Preprint]. 2023 May 30:rs.3.rs-2960526. doi: 10.21203/rs.3.rs-2960526/v1.
Res Sq. 2023.
PMID: 37398159
Free PMC article.
Preprint.
Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis.
Okaa UJ, Bertuzzi M, Fortune-Grant R, Thomson DD, Moyes DL, Naglik JR, Bignell E.
Okaa UJ, et al. Among authors: fortune grant r.
Infect Immun. 2023 Feb 16;91(2):e0033322. doi: 10.1128/iai.00333-22. Epub 2023 Jan 10.
Infect Immun. 2023.
PMID: 36625602
Free PMC article.
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Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms.
Rahman S, van Rhijn N, Papastamoulis P, Thomson DD, Carter Z, Fortune-Grant R, Rattray M, Bromley MJ, Bignell E.
Rahman S, et al. Among authors: fortune grant r.
Front Cell Infect Microbiol. 2022 Jul 28;12:907519. doi: 10.3389/fcimb.2022.907519. eCollection 2022.
Front Cell Infect Microbiol. 2022.
PMID: 35982778
Free PMC article.
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Exploring a novel genomic safe-haven site in the human pathogenic mould Aspergillus fumigatus.
Furukawa T, van Rhijn N, Chown H, Rhodes J, Alfuraiji N, Fortune-Grant R, Bignell E, Fisher MC, Bromley M.
Furukawa T, et al. Among authors: fortune grant r.
Fungal Genet Biol. 2022 Jul;161:103702. doi: 10.1016/j.fgb.2022.103702. Epub 2022 May 13.
Fungal Genet Biol. 2022.
PMID: 35569804
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Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.
Sueiro-Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, Zivanovic J, Yu Y, Strobel M, Cunha C, Thomson D, Fortune-Grant R, Thusek S, Bowyer P, Beilhack A, Carvalho A, Bignell E, Filipovic MR, Amich J.
Sueiro-Olivares M, et al. Among authors: fortune grant r.
PLoS Biol. 2021 Jun 1;19(6):e3001247. doi: 10.1371/journal.pbio.3001247. eCollection 2021 Jun.
PLoS Biol. 2021.
PMID: 34061822
Free PMC article.
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Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence.
Scott J, Sueiro-Olivares M, Thornton BP, Owens RA, Muhamadali H, Fortune-Grant R, Thomson D, Thomas R, Hollywood K, Doyle S, Goodacre R, Tabernero L, Bignell E, Amich J.
Scott J, et al. Among authors: fortune grant r.
mBio. 2020 Oct 13;11(5):e01985-20. doi: 10.1128/mBio.01985-20.
mBio. 2020.
PMID: 33051366
Free PMC article.
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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ.
Furukawa T, et al. Among authors: fortune grant r.
Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1.
Nat Commun. 2020.
PMID: 31969561
Free PMC article.
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Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility.
Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM.
Hwang SJ, et al. Among authors: fortune grant r.
J Physiol. 2019 May;597(9):2337-2360. doi: 10.1113/JP277335. Epub 2019 Mar 28.
J Physiol. 2019.
PMID: 30843201
Free PMC article.
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