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A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. Hemnes AR, et al. Eur Respir J. 2018 Jun 21;51(6):1702638. doi: 10.1183/13993003.02638-2017. Print 2018 Jun. Eur Respir J. 2018. PMID: 29903860 Free PMC article. Clinical Trial.
Human PAH is characterized by a pattern of lipid-related insulin resistance.
Hemnes AR, Luther JM, Rhodes CJ, Burgess JP, Carlson J, Fan R, Fessel JP, Fortune N, Gerszten RE, Halliday SJ, Hekmat R, Howard L, Newman JH, Niswender KD, Pugh ME, Robbins IM, Sheng Q, Shibao CA, Shyr Y, Sumner S, Talati M, Wharton J, Wilkins MR, Ye F, Yu C, West J, Brittain EL. Hemnes AR, et al. JCI Insight. 2019 Jan 10;4(1):e123611. doi: 10.1172/jci.insight.123611. JCI Insight. 2019. PMID: 30626738 Free PMC article.
BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.
Hemnes AR, Fessel JP, Chen X, Zhu S, Fortune NL, Jetter C, Freeman M, Newman JH, West JD, Talati MH. Hemnes AR, et al. Among authors: fortune nl. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L429-L441. doi: 10.1152/ajplung.00555.2018. Epub 2019 Dec 18. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31850803 Free PMC article.
Natriuretic peptide receptor C contributes to disproportionate right ventricular hypertrophy in a rodent model of obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension.
Agrawal V, Fortune N, Yu S, Fuentes J, Shi F, Nichols D, Gleaves L, Poovey E, Wang TJ, Brittain EL, Collins S, West JD, Hemnes AR. Agrawal V, et al. Pulm Circ. 2019 Dec 18;9(4):2045894019878599. doi: 10.1177/2045894019895452. eCollection 2019 Oct-Dec. Pulm Circ. 2019. PMID: 31903184 Free PMC article.
14 results