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An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid.
Perrone MG, Miciaccia M, Vitale P, Ferorelli S, Araújo CDCB, de Almeida GS, Souza Domingos TF, da Silva LCRP, de Pádula M, Cabral LM, Sathler PC, Bonaccorso C, Fortuna CG, Scilimati A. Perrone MG, et al. Among authors: fortuna cg. Eur J Med Chem. 2021 Jan 1;209:112919. doi: 10.1016/j.ejmech.2020.112919. Epub 2020 Oct 9. Eur J Med Chem. 2021. PMID: 33129592
New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles.
Fortuna CG, Berardozzi R, Bonaccorso C, Caltabiano G, Di Bari L, Goracci L, Guarcello A, Pace A, Palumbo Piccionello A, Pescitelli G, Pierro P, Lonati E, Bulbarelli A, Cocuzza CE, Musumarra G, Musumeci R. Fortuna CG, et al. Bioorg Med Chem. 2014 Dec 15;22(24):6814-25. doi: 10.1016/j.bmc.2014.10.037. Epub 2014 Nov 1. Bioorg Med Chem. 2014. PMID: 25464880
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).
Cingolani G, Panella A, Perrone MG, Vitale P, Di Mauro G, Fortuna CG, Armen RS, Ferorelli S, Smith WL, Scilimati A. Cingolani G, et al. Among authors: fortuna cg. Eur J Med Chem. 2017 Sep 29;138:661-668. doi: 10.1016/j.ejmech.2017.06.045. Epub 2017 Jun 24. Eur J Med Chem. 2017. PMID: 28710965 Free PMC article.
54 results