Forster M - Search Results

1

tert-Butyl N-[(3R,4R)-1-(2-cyano-acet-yl)-4-methyl-piperidin-3-yl]-N-methyl-carbamate.

Gehringer M, Forster M, Schollmeyer D, Laufer S. Gehringer M, et al. Among authors: forster m. Acta Crystallogr Sect E Struct Rep Online. 2013 May 22;69(Pt 6):o935. doi: 10.1107/S1600536813013512. Print 2013 Jun 1. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 23795101 Free PMC article.

2

Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.

Gehringer M, Forster M, Pfaffenrot E, Bauer SM, Laufer SA. Gehringer M, et al. Among authors: forster m. ChemMedChem. 2014 Nov;9(11):2516-27. doi: 10.1002/cmdc.201402252. Epub 2014 Aug 19. ChemMedChem. 2014. PMID: 25139757

3

Solution-phase parallel synthesis of ruxolitinib-derived Janus kinase inhibitors via copper-catalyzed azide-alkyne cycloaddition.

Gehringer M, Forster M, Laufer SA. Gehringer M, et al. Among authors: forster m. ACS Comb Sci. 2015 Jan 12;17(1):5-10. doi: 10.1021/co500122h. Epub 2014 Dec 1. ACS Comb Sci. 2015. PMID: 25405713

4

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

Ostrovskyi D, Rumpf T, Eib J, Lumbroso A, Slynko I, Klaeger S, Heinzlmeir S, Forster M, Gehringer M, Pfaffenrot E, Bauer SM, Schmidtkunz K, Wenzler S, Metzger E, Kuster B, Laufer S, Schüle R, Sippl W, Breit B, Jung M. Ostrovskyi D, et al. Among authors: forster m. Future Med Chem. 2016 Sep;8(13):1537-51. doi: 10.4155/fmc-2016-0132. Epub 2016 Aug 30. Future Med Chem. 2016. PMID: 27572962

5

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.

Forster M, Chaikuad A, Bauer SM, Holstein J, Robers MB, Corona CR, Gehringer M, Pfaffenrot E, Ghoreschi K, Knapp S, Laufer SA. Forster M, et al. Cell Chem Biol. 2016 Nov 17;23(11):1335-1340. doi: 10.1016/j.chembiol.2016.10.008. Epub 2016 Nov 10. Cell Chem Biol. 2016. PMID: 27840070 Free PMC article.

6

Recent advances in JAK3 inhibition: Isoform selectivity by covalent cysteine targeting.

Forster M, Gehringer M, Laufer SA. Forster M, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4229-4237. doi: 10.1016/j.bmcl.2017.07.079. Epub 2017 Jul 29. Bioorg Med Chem Lett. 2017. PMID: 28844493 Review.

7

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors.

Andreev S, Pantsar T, Ansideri F, Kudolo M, Forster M, Schollmeyer D, Laufer SA, Koch P. Andreev S, et al. Among authors: forster m. Molecules. 2019 Jun 25;24(12):2331. doi: 10.3390/molecules24122331. Molecules. 2019. PMID: 31242571 Free PMC article.

8

Development, Optimization, and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4- d]pyrrolo[2,3- b]pyridine Scaffold.

Forster M, Chaikuad A, Dimitrov T, Döring E, Holstein J, Berger BT, Gehringer M, Ghoreschi K, Müller S, Knapp S, Laufer SA. Forster M, et al. J Med Chem. 2018 Jun 28;61(12):5350-5366. doi: 10.1021/acs.jmedchem.8b00571. Epub 2018 Jun 13. J Med Chem. 2018. PMID: 29852068

9

Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells.

Laux J, Forster M, Riexinger L, Schwamborn A, Guezguez J, Pokoj C, Kudolo M, Berger LM, Knapp S, Schollmeyer D, Guse J, Burnet M, Laufer SA. Laux J, et al. Among authors: forster m. ACS Pharmacol Transl Sci. 2022 Jul 14;5(8):573-602. doi: 10.1021/acsptsci.2c00054. eCollection 2022 Aug 12. ACS Pharmacol Transl Sci. 2022. PMID: 35983274 Free PMC article.

10

An updated patent review of p38 MAP kinase inhibitors (2014-2019).

Haller V, Nahidino P, Forster M, Laufer SA. Haller V, et al. Among authors: forster m. Expert Opin Ther Pat. 2020 Jun;30(6):453-466. doi: 10.1080/13543776.2020.1749263. Epub 2020 Apr 20. Expert Opin Ther Pat. 2020. PMID: 32228113 Review.

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