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Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production.
Hulme BJ, Geyer KK, Forde-Thomas JE, Padalino G, Phillips DW, Ittiprasert W, Karinshak SE, Mann VH, Chalmers IW, Brindley PJ, Hokke CH, Hoffmann KF. Hulme BJ, et al. Among authors: forde thomas je. PLoS Pathog. 2022 Jan 13;18(1):e1009828. doi: 10.1371/journal.ppat.1009828. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35025955 Free PMC article.
An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni.
Whiteland HL, Chakroborty A, Forde-Thomas JE, Crusco A, Cookson A, Hollinshead J, Fenn CA, Bartholomew B, Holdsworth PA, Fisher M, Nash RJ, Hoffmann KF. Whiteland HL, et al. Among authors: forde thomas je. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):465-474. doi: 10.1016/j.ijpddr.2018.10.009. Epub 2018 Oct 26. Int J Parasitol Drugs Drug Resist. 2018. PMID: 30399512 Free PMC article.
Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.
Whiteland H, Crusco A, Bloemberg LW, Tibble-Howlings J, Forde-Thomas J, Coghlan A, Murphy PJ, Hoffmann KF. Whiteland H, et al. PLoS Negl Trop Dis. 2020 Oct 19;14(10):e0008630. doi: 10.1371/journal.pntd.0008630. eCollection 2020 Oct. PLoS Negl Trop Dis. 2020. PMID: 33075069 Free PMC article.
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.
Partridge FA, Bataille CJR, Forman R, Marriott AE, Forde-Thomas J, Häberli C, Dinsdale RL, O'Sullivan JDB, Willis NJ, Wynne GM, Whiteland H, Archer J, Steven A, Keiser J, Turner JD, Hoffmann KF, Taylor MJ, Else KJ, Russell AJ, Sattelle DB. Partridge FA, et al. ACS Infect Dis. 2021 May 14;7(5):1260-1274. doi: 10.1021/acsinfecdis.1c00025. Epub 2021 Apr 2. ACS Infect Dis. 2021. PMID: 33797218 Free PMC article.
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF. Padalino G, et al. Eur J Med Chem. 2021 Dec 15;226:113823. doi: 10.1016/j.ejmech.2021.113823. Epub 2021 Sep 10. Eur J Med Chem. 2021. PMID: 34536671 Free PMC article.
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.
Gasan TA, Kuipers ME, Roberts GH, Padalino G, Forde-Thomas JE, Wilson S, Wawrzyniak J, Tukahebwa EM, Hoffmann KF, Chalmers IW. Gasan TA, et al. Among authors: forde thomas je. PLoS Negl Trop Dis. 2021 Nov 18;15(11):e0009981. doi: 10.1371/journal.pntd.0009981. eCollection 2021 Nov. PLoS Negl Trop Dis. 2021. PMID: 34793443 Free PMC article.
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