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New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads.
Fonte M, Fontinha D, Moita D, Caño-Prades O, Avalos-Padilla Y, Fernàndez-Busquets X, Prudêncio M, Gomes P, Teixeira C. Fonte M, et al. Among authors: fontinha d. Eur J Med Chem. 2023 Oct 5;258:115575. doi: 10.1016/j.ejmech.2023.115575. Epub 2023 Jun 22. Eur J Med Chem. 2023. PMID: 37390511 Free article.
Primaquine hybrids as promising antimycobacterial and antimalarial agents.
Pavić K, Perković I, Pospíšilová Š, Machado M, Fontinha D, Prudêncio M, Jampilek J, Coffey A, Endersen L, Rimac H, Zorc B. Pavić K, et al. Among authors: fontinha d. Eur J Med Chem. 2018 Jan 1;143:769-779. doi: 10.1016/j.ejmech.2017.11.083. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29220797
Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.
Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K. Kumar M, et al. Among authors: fontinha d. ACS Infect Dis. 2019 Feb 8;5(2):303-315. doi: 10.1021/acsinfecdis.8b00272. Epub 2019 Jan 7. ACS Infect Dis. 2019. PMID: 30525439
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K. Mayoka G, et al. Among authors: fontinha d. J Med Chem. 2019 Jan 24;62(2):1022-1035. doi: 10.1021/acs.jmedchem.8b01769. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30562027
Primaquine homodimers as potential antiplasmodial and anticancer agents.
Pavić K, Rubinić B, Rajić Z, Fontinha D, Prudêncio M, Uzelac L, Kralj M, Held J, Zorc B. Pavić K, et al. Among authors: fontinha d. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126614. doi: 10.1016/j.bmcl.2019.08.018. Epub 2019 Aug 10. Bioorg Med Chem Lett. 2019. PMID: 31431364
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