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JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats.
Wong-Guerra M, Montano-Peguero Y, Ramírez-Sánchez J, Jiménez-Martin J, Fonseca-Fonseca LA, Hernández-Enseñat D, Nonose Y, Valdés O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto Del Valle RM, Pardo-Andreu G, Outeiro TF, Padrón-Yaquis AS, Martimbianco de Assis A, O Souza D, Nuñez-Figueredo Y. Wong-Guerra M, et al. Among authors: fonseca fonseca la. Neurotoxicology. 2021 Dec;87:70-85. doi: 10.1016/j.neuro.2021.08.017. Epub 2021 Sep 2. Neurotoxicology. 2021. PMID: 34481871
Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway.
Ramírez-Sánchez J, Simões Pires EN, Nuñez-Figueredo Y, Pardo-Andreu GL, Fonseca-Fonseca LA, Ruiz-Reyes A, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Souza DO, Salbego C. Ramírez-Sánchez J, et al. Among authors: fonseca fonseca la. Neurochem Int. 2015 Nov;90:215-23. doi: 10.1016/j.neuint.2015.09.003. Epub 2015 Sep 8. Neurochem Int. 2015. PMID: 26361722
Mitochondrial involvement in memory impairment induced by scopolamine in rats.
Wong-Guerra M, Jiménez-Martin J, Pardo-Andreu GL, Fonseca-Fonseca LA, Souza DO, de Assis AM, Ramirez-Sanchez J, Del Valle RM, Nuñez-Figueredo Y. Wong-Guerra M, et al. Among authors: fonseca fonseca la. Neurol Res. 2017 Jul;39(7):649-659. doi: 10.1080/01616412.2017.1312775. Epub 2017 Apr 11. Neurol Res. 2017. PMID: 28398193
KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity.
Fonseca-Fonseca LA, Nuñez-Figueredo Y, Sánchez JR, Guerra MW, Ochoa-Rodríguez E, Verdecia-Reyes Y, Hernádez RD, Menezes-Filho NJ, Costa TCS, de Santana WA, Oliveira JL, Segura-Aguilar J, da Silva VDA, Costa SL. Fonseca-Fonseca LA, et al. Neurotox Res. 2019 Aug;36(2):279-291. doi: 10.1007/s12640-017-9851-5. Epub 2018 Jan 2. Neurotox Res. 2019. PMID: 29294239
JM-20 protects memory acquisition and consolidation on scopolamine model of cognitive impairment.
Wong-Guerra M, Jiménez-Martin J, Fonseca-Fonseca LA, Ramírez-Sánchez J, Montano-Peguero Y, Rocha JB, D Avila F, de Assis AM, Souza DO, Pardo-Andreu GL, Del Valle RM, Lopez GA, Martínez OV, García NM, Mondelo-Rodríguez A, Padrón-Yaquis AS, Nuñez-Figueredo Y. Wong-Guerra M, et al. Among authors: fonseca fonseca la. Neurol Res. 2019 May;41(5):385-398. doi: 10.1080/01616412.2019.1573285. Epub 2019 Mar 1. Neurol Res. 2019. PMID: 30821663
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. Neurotoxicology. 2021. PMID: 33232743 Free article.
Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion.
Ramírez-Sánchez J, Wong-Guerra M, Fonseca-Fonseca LA, Simões-Pires EN, García-Pupo L, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Salbego C, Souza DO, Pardo-Andreu GL, Nuñez-Figueredo Y. Ramírez-Sánchez J, et al. Among authors: fonseca fonseca la. Eur J Pharmacol. 2021 May 15;899:174025. doi: 10.1016/j.ejphar.2021.174025. Epub 2021 Mar 17. Eur J Pharmacol. 2021. PMID: 33722590 Free article.
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species.
Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Muñoz P, Almeida ÁMAN, Costa ACS, Teles-Souza J, Ochoa-Rodríguez E, de Fátima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, Dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Núñez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA. Santos CC, et al. Among authors: fonseca fonseca la. Neurotox Res. 2022 Dec;40(6):2135-2147. doi: 10.1007/s12640-022-00559-7. Epub 2022 Aug 23. Neurotox Res. 2022. PMID: 35997936
Corrigendum to "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats" [Neurotoxicology 87 (2021) 70-85].
Wong-Guerra M, Montano-Peguero Y, Ramírez-Sánchez J, Jiménez-Martin J, Fonseca-Fonseca LA, Hernández-Enseñat D, Nonose Y, Valdés O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto Del Valle RM, Pardo-Andreu G, Outeiro TF, Padrón-Yaquis AS, de Assis AM, Souza DO, Nuñez-Figueredo Y. Wong-Guerra M, et al. Among authors: fonseca fonseca la. Neurotoxicology. 2023 Dec;99:10-13. doi: 10.1016/j.neuro.2023.09.003. Epub 2023 Sep 10. Neurotoxicology. 2023. PMID: 37699281 No abstract available.