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Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
Fonseca EMB, Trivella DBB, Scorsato V, Dias MP, Bazzo NL, Mandapati KR, de Oliveira FL, Ferreira-Halder CV, Pilli RA, Miranda PCML, Aparicio R. Fonseca EMB, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4462-4471. doi: 10.1016/j.bmc.2015.06.017. Epub 2015 Jun 14. Bioorg Med Chem. 2015. PMID: 26117648
Oncophosphosignaling Favors a Glycolytic Phenotype in Human Drug Resistant Leukemia.
Faria AVS, Tornatore TF, Milani R, Queiroz KCS, Sampaio IH, Fonseca EMB, Rocha-Brito KJP, Santos TO, Silveira LR, Peppelenbosch MP, Ferreira-Halder CV. Faria AVS, et al. Among authors: fonseca emb. J Cell Biochem. 2017 Nov;118(11):3846-3854. doi: 10.1002/jcb.26034. Epub 2017 May 23. J Cell Biochem. 2017. PMID: 28387439
Conformational variability of the stationary phase survival protein E from Xylella fastidiosa revealed by X-ray crystallography, small-angle X-ray scattering studies, and normal mode analysis.
Machado ATP, Fonseca EMB, Reis MAD, Saraiva AM, Santos CAD, de Toledo MAS, Polikarpov I, de Souza AP, Aparicio R, Iulek J. Machado ATP, et al. Among authors: fonseca emb. Proteins. 2017 Oct;85(10):1931-1943. doi: 10.1002/prot.25347. Epub 2017 Jul 24. Proteins. 2017. PMID: 28677327