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A divergent breakdown of neurocognitive networks in Parkinson's Disease mild cognitive impairment.
Aracil-Bolaños I, Sampedro F, Marín-Lahoz J, Horta-Barba A, Martínez-Horta S, Botí M, Pérez-Pérez J, Bejr-Kasem H, Pascual-Sedano B, Campolongo A, Izquierdo C, Gironell A, Gómez-Ansón B, Kulisevsky J, Pagonabarraga J. Aracil-Bolaños I, et al. Hum Brain Mapp. 2019 Aug 1;40(11):3233-3242. doi: 10.1002/hbm.24593. Epub 2019 Apr 1. Hum Brain Mapp. 2019. PMID: 30938027 Free PMC article.
Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.
Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA. Cuyàs E, et al. Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8. Aging Cell. 2018. PMID: 29740925 Free PMC article.
Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for decades in the absence of a complete understanding of its therapeutic targets or chemical determinants. ...
Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically ex …