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Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson's associated GBA gene.
X-Q Chen C, Deneault E, Abdian N, You Z, Sirois J, Nicouleau M, Shlaifer I, Villegas L, Boivin MN, Gaborieau L, Karamchandani J, Beitel LK, Fon EA, Durcan TM. X-Q Chen C, et al. Among authors: fon ea. Stem Cell Res. 2022 Oct;64:102919. doi: 10.1016/j.scr.2022.102919. Epub 2022 Sep 15. Stem Cell Res. 2022. PMID: 36130446 Free article.
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA. Durcan TM, et al. Among authors: fon ea. EMBO J. 2014 Nov 3;33(21):2473-91. doi: 10.15252/embj.201489729. Epub 2014 Sep 12. EMBO J. 2014. PMID: 25216678 Free PMC article.
USP8 and PARK2/parkin-mediated mitophagy.
Durcan TM, Fon EA. Durcan TM, et al. Among authors: fon ea. Autophagy. 2015;11(2):428-9. doi: 10.1080/15548627.2015.1009794. Autophagy. 2015. PMID: 25700639 Free PMC article.
146 results