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Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant.
Blood. 2006 Aug 15;108(4):1374-6. doi: 10.1182/blood-2006-02-004457. Epub 2006 Apr 27.
Blood. 2006.
PMID: 16645167
Free PMC article.
Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate.
Prenen H, Cools J, Mentens N, Folens C, Sciot R, Schöffski P, Van Oosterom A, Marynen P, Debiec-Rychter M.
Prenen H, et al. Among authors: folens c.
Clin Cancer Res. 2006 Apr 15;12(8):2622-7. doi: 10.1158/1078-0432.CCR-05-2275.
Clin Cancer Res. 2006.
PMID: 16638875
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Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.
Stover EH, Chen J, Folens C, Lee BH, Mentens N, Marynen P, Williams IR, Gilliland DG, Cools J.
Stover EH, et al. Among authors: folens c.
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8078-83. doi: 10.1073/pnas.0601192103. Epub 2006 May 11.
Proc Natl Acad Sci U S A. 2006.
PMID: 16690743
Free PMC article.
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In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.
De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J.
De Keersmaecker K, et al. Among authors: folens c.
Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5.
Haematologica. 2008.
PMID: 18322257
Free article.
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Kinase activation and transformation by NUP214-ABL1 is dependent on the context of the nuclear pore.
De Keersmaecker K, Rocnik JL, Bernad R, Lee BH, Leeman D, Gielen O, Verachtert H, Folens C, Munck S, Marynen P, Fornerod M, Gilliland DG, Cools J.
De Keersmaecker K, et al. Among authors: folens c.
Mol Cell. 2008 Jul 11;31(1):134-42. doi: 10.1016/j.molcel.2008.05.005.
Mol Cell. 2008.
PMID: 18614052
Free article.
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A new NDE1/PDGFRB fusion transcript underlying chronic myelomonocytic leukaemia in Noonan Syndrome.
La Starza R, Rosati R, Roti G, Gorello P, Bardi A, Crescenzi B, Pierini V, Calabrese O, Baens M, Folens C, Cools J, Marynen P, Martelli MF, Mecucci C, Cuneo A.
La Starza R, et al. Among authors: folens c.
Leukemia. 2007 Apr;21(4):830-3. doi: 10.1038/sj.leu.2404541. Epub 2007 Feb 15.
Leukemia. 2007.
PMID: 17301821
Free article.
No abstract available.
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