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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1.
Gallage S, Ali A, Barragan Avila JE, Seymen N, Ramadori P, Joerke V, Zizmare L, Aicher D, Gopalsamy IK, Fong W, Kosla J, Focaccia E, Li X, Yousuf S, Sijmonsma T, Rahbari M, Kommoss KS, Billeter A, Prokosch S, Rothermel U, Mueller F, Hetzer J, Heide D, Schinkel B, Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M. Gallage S, et al. Among authors: focaccia e. Cell Metab. 2024 May 2:S1550-4131(24)00135-9. doi: 10.1016/j.cmet.2024.04.015. Online ahead of print. Cell Metab. 2024. PMID: 38718791 Free article.
Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma.
Zheng C, Snow BE, Elia AJ, Nechanitzky R, Dominguez-Brauer C, Liu S, Tong Y, Cox MA, Focaccia E, Wakeham AC, Haight J, Tobin C, Hodgson K, Gill KT, Ma W, Berger T, Heikenwälder M, Saunders ME, Fortin J, Leung SY, Mak TW. Zheng C, et al. Among authors: focaccia e. Nat Cancer. 2023 Oct;4(10):1437-1454. doi: 10.1038/s43018-023-00624-w. Epub 2023 Aug 28. Nat Cancer. 2023. PMID: 37640929 Free PMC article.
A researcher's guide to preclinical mouse NASH models.
Gallage S, Avila JEB, Ramadori P, Focaccia E, Rahbari M, Ali A, Malek NP, Anstee QM, Heikenwalder M. Gallage S, et al. Among authors: focaccia e. Nat Metab. 2022 Dec;4(12):1632-1649. doi: 10.1038/s42255-022-00700-y. Epub 2022 Dec 20. Nat Metab. 2022. PMID: 36539621 Review.
JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
Müller K, Honcharova-Biletska H, Koppe C, Egger M, Chan LK, Schneider AT, Küsgens L, Böhm F, Boege Y, Healy ME, Schmitt J, Comtesse S, Castoldi M, Preisinger C, Szydlowska M, Focaccia E, Gaisa NT, Loosen SH, Jörs S, Tacke F, Roderburg C, Keitel V, Bode JG, Boor P, Davis RJ, Longerich T, Geisler F, Heikenwalder M, Weber A, Vucur M, Luedde T. Müller K, et al. Among authors: focaccia e. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2007194118. doi: 10.1073/pnas.2007194118. Proc Natl Acad Sci U S A. 2021. PMID: 33798093 Free PMC article.
Therapeutic potential of nvp-bkm120 in human osteosarcomas cells.
Bavelloni A, Focaccia E, Piazzi M, Orsini A, Ramazzotti G, Cocco L, Blalock W, Faenza I. Bavelloni A, et al. Among authors: focaccia e. J Cell Physiol. 2019 Jul;234(7):10907-10917. doi: 10.1002/jcp.27911. Epub 2018 Dec 7. J Cell Physiol. 2019. PMID: 30536897
MiRNA-210: A Current Overview.
Bavelloni A, Ramazzotti G, Poli A, Piazzi M, Focaccia E, Blalock W, Faenza I. Bavelloni A, et al. Among authors: focaccia e. Anticancer Res. 2017 Dec;37(12):6511-6521. doi: 10.21873/anticanres.12107. Anticancer Res. 2017. PMID: 29187425 Review.