Flynn B - Search Results

1

The role of dihydrosphingolipids in disease.

Magaye RR, Savira F, Hua Y, Kelly DJ, Reid C, Flynn B, Liew D, Wang BH. Magaye RR, et al. Among authors: flynn b. Cell Mol Life Sci. 2019 Mar;76(6):1107-1134. doi: 10.1007/s00018-018-2984-8. Epub 2018 Dec 6. Cell Mol Life Sci. 2019. PMID: 30523364 Review.

2

Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.

Savira F, Magaye R, Scullino CV, Flynn BL, Pitson SM, Anderson D, Creek DJ, Hua Y, Xiong X, Huang L, Liew D, Reid C, Kaye D, Kompa AR, Wang BH. Savira F, et al. Toxicol Lett. 2021 Oct 10;350:133-142. doi: 10.1016/j.toxlet.2021.07.012. Epub 2021 Jul 22. Toxicol Lett. 2021. PMID: 34303789

3

The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate.

Savira F, Kompa AR, Kelly DJ, Magaye R, Xiong X, Huang L, Liew D, Reid C, Kaye D, Scullino CV, Pitson SM, Flynn BL, Wang BH. Savira F, et al. Vascul Pharmacol. 2021 Dec;141:106923. doi: 10.1016/j.vph.2021.106923. Epub 2021 Sep 29. Vascul Pharmacol. 2021. PMID: 34600152

4

Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells.

Magaye RR, Savira F, Hua Y, Xiong X, Huang L, Reid C, Flynn BL, Kaye D, Liew D, Wang BH. Magaye RR, et al. Int J Biochem Cell Biol. 2021 May;134:105952. doi: 10.1016/j.biocel.2021.105952. Epub 2021 Feb 17. Int J Biochem Cell Biol. 2021. PMID: 33609744

5

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts.

Magaye RR, Savira F, Xiong X, Huynh K, Meikle PJ, Reid C, Flynn BL, Kaye D, Liew D, Wang BH. Magaye RR, et al. Int J Cardiol Heart Vasc. 2021 Jul 6;35:100837. doi: 10.1016/j.ijcha.2021.100837. eCollection 2021 Aug. Int J Cardiol Heart Vasc. 2021. PMID: 34277924 Free PMC article.

6

Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.

Magaye RR, Savira F, Hua Y, Xiong X, Huang L, Reid C, Flynn B, Kaye D, Liew D, Wang BH. Magaye RR, et al. Among authors: flynn b. Cell Signal. 2020 Aug;72:109629. doi: 10.1016/j.cellsig.2020.109629. Epub 2020 Apr 8. Cell Signal. 2020. PMID: 32278008

7

Asymmetric synthesis of (+)- and (-)-pauciflorol F: confirmation of absolute stereochemistry.

Kerr DJ, Miletic M, Manchala N, White JM, Flynn BL. Kerr DJ, et al. Org Lett. 2013 Aug 16;15(16):4118-21. doi: 10.1021/ol401752u. Epub 2013 Jul 30. Org Lett. 2013. PMID: 23899350

8

Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades.

Halim R, Aurelio L, Scammells PJ, Flynn BL. Halim R, et al. J Org Chem. 2013 May 17;78(10):4708-18. doi: 10.1021/jo400125p. Epub 2013 May 9. J Org Chem. 2013. PMID: 23659428

9

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL. Aurelio L, et al. J Med Chem. 2016 Feb 11;59(3):965-84. doi: 10.1021/acs.jmedchem.5b01439. Epub 2016 Feb 3. J Med Chem. 2016. PMID: 26780304

10

Alkyne Activation in the Diversity Oriented Synthesis of sp² -Rich Scaffolds: A Biased Library Approach for Targeting Polynucleotides (DNA/RNA).

Chen S, Priebbenow DL, Somkhit J, Scullino CV, Agama K, Pommier Y, Flynn BL. Chen S, et al. Chemistry. 2022 Dec 20;28(71):e202201925. doi: 10.1002/chem.202201925. Epub 2022 Nov 3. Chemistry. 2022. PMID: 36069042 Free PMC article.

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