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Human radical scavenger α1-microglobulin protects against hemolysis in vitro and α1-microglobulin knockout mice exhibit a macrocytic anemia phenotype.
Kristiansson A, Bergwik J, Alattar AG, Flygare J, Gram M, Hansson SR, Olsson ML, Storry JR, Allhorn M, Åkerström B. Kristiansson A, et al. Among authors: flygare j. Free Radic Biol Med. 2021 Jan;162:149-159. doi: 10.1016/j.freeradbiomed.2020.02.018. Epub 2020 Feb 21. Free Radic Biol Med. 2021. PMID: 32092412
Targeting elevated heme levels to treat a mouse model for Diamond-Blackfan Anemia.
Sjögren SE, Chen J, Mattebo A, Alattar AG, Karlsson H, Siva K, Soneji S, Tedgård U, Chen JJ, Gram M, Flygare J. Sjögren SE, et al. Among authors: flygare j. Exp Hematol. 2022 Jan;105:50-61. doi: 10.1016/j.exphem.2021.10.005. Epub 2021 Oct 30. Exp Hematol. 2022. PMID: 34757171 Free PMC article.
Recombinant α1-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a 177Lu-DOTATATE Mouse Radiation Model.
Alattar AG, Kristiansson A, Karlsson H, Vallius S, Ahlstedt J, Forssell-Aronsson E, Åkerström B, Strand SE, Flygare J, Gram M. Alattar AG, et al. Among authors: flygare j. Biomolecules. 2023 Jun 1;13(6):928. doi: 10.3390/biom13060928. Biomolecules. 2023. PMID: 37371508 Free PMC article.
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Wilkes MC, Siva K, Chen J, Varetti G, Youn MY, Chae H, Ek F, Olsson R, Lundbäck T, Dever DP, Nishimura T, Narla A, Glader B, Nakauchi H, Porteus MH, Repellin CE, Gazda HT, Lin S, Serrano M, Flygare J, Sakamoto KM. Wilkes MC, et al. Among authors: flygare j. Nat Commun. 2020 Jul 3;11(1):3344. doi: 10.1038/s41467-020-17100-z. Nat Commun. 2020. PMID: 32620751 Free PMC article.
Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.
Wilkes MC, Siva K, Varetti G, Mercado J, Wentworth EP, Perez CA, Saxena M, Kam S, Kapur S, Chen J, Narla A, Glader B, Lin S, Serrano M, Flygare J, Sakamoto KM. Wilkes MC, et al. Among authors: flygare j. Exp Hematol. 2020 Nov;91:65-77. doi: 10.1016/j.exphem.2020.09.187. Epub 2020 Sep 12. Exp Hematol. 2020. PMID: 32926965 Free PMC article.
Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
Taylor AM, Macari ER, Chan IT, Blair MC, Doulatov S, Vo LT, Raiser DM, Siva K, Basak A, Pirouz M, Shah AN, McGrath K, Humphries JM, Stillman E, Alter BP, Calo E, Gregory RI, Sankaran VG, Flygare J, Ebert BL, Zhou Y, Daley GQ, Zon LI. Taylor AM, et al. Among authors: flygare j. Sci Transl Med. 2020 Oct 21;12(566):eabb5831. doi: 10.1126/scitranslmed.abb5831. Sci Transl Med. 2020. PMID: 33087503 Free PMC article.
Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
Mattebo A, Sen T, Jassinskaja M, Pimková K, Prieto González-Albo I, Alattar AG, Ramakrishnan R, Lang S, Järås M, Hansson J, Soneji S, Singbrant S, van den Akker E, Flygare J. Mattebo A, et al. Among authors: flygare j. Sci Rep. 2021 Aug 5;11(1):15898. doi: 10.1038/s41598-021-95291-1. Sci Rep. 2021. PMID: 34354145 Free PMC article.
121 results