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Page 1
Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice.
Grigoryan L, Lee A, Walls AC, Lai L, Franco B, Arunachalam PS, Feng Y, Luo W, Vanderheiden A, Floyd K, Wrenn S, Pettie D, Miranda MC, Kepl E, Ravichandran R, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, Coffman RL, Novack D, Kleanthous H, O'Hagan DT, van der Most R, McLellan JS, Suthar M, Veesler D, King NP, Pulendran B. Grigoryan L, et al. Among authors: floyd k. NPJ Vaccines. 2022 May 23;7(1):55. doi: 10.1038/s41541-022-00472-2. NPJ Vaccines. 2022. PMID: 35606518 Free PMC article.
Infection and mRNA-1273 vaccine antibodies neutralize SARS-CoV-2 UK variant.
Edara VV, Floyd K, Lai L, Gardner M, Hudson W, Piantadosi A, Waggoner JJ, Babiker A, Ahmed R, Xie X, Lokugamage K, Menachery V, Shi PY, Suthar MS. Edara VV, et al. Among authors: floyd k. medRxiv [Preprint]. 2021 Feb 5:2021.02.02.21250799. doi: 10.1101/2021.02.02.21250799. medRxiv. 2021. PMID: 33564782 Free PMC article. Preprint.
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Routhu NK, Cheedarla N, Gangadhara S, Bollimpelli VS, Boddapati AK, Shiferaw A, Rahman SA, Sahoo A, Edara VV, Lai L, Floyd K, Wang S, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Upadhyay AA, Pellegrini K, Montefiori D, Shi PY, Menachery VD, Alter G, Vanderford TH, Bosinger SE, Suthar MS, Amara RR. Routhu NK, et al. Among authors: floyd k. Immunity. 2021 Mar 9;54(3):542-556.e9. doi: 10.1016/j.immuni.2021.02.001. Epub 2021 Feb 4. Immunity. 2021. PMID: 33631118 Free PMC article.
Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates.
Francica JR, Flynn BJ, Foulds KE, Noe AT, Werner AP, Moore IN, Gagne M, Johnston TS, Tucker C, Davis RL, Flach B, O'Connell S, Andrew SF, Lamb E, Flebbe DR, Nurmukhambetova ST, Donaldson MM, Todd JM, Zhu AL, Atyeo C, Fischinger S, Gorman MJ, Shin S, Edara VV, Floyd K, Lai L, Tylor A, McCarthy E, Lecouturier V, Ruiz S, Berry C, Tibbitts T, Andersen H, Cook A, Dodson A, Pessaint L, Ry AV, Koutsoukos M, Gutzeit C, Teng IT, Zhou T, Li D, Haynes BF, Kwong PD, McDermott A, Lewis MG, Fu TM, Chicz R, van der Most R, Corbett KS, Suthar MS, Alter G, Roederer M, Sullivan NJ, Douek DC, Graham BS, Casimiro D, Seder RA. Francica JR, et al. Among authors: floyd k. bioRxiv [Preprint]. 2021 Mar 2:2021.03.02.433390. doi: 10.1101/2021.03.02.433390. bioRxiv. 2021. PMID: 33688652 Free PMC article. Preprint.
Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant.
Edara VV, Norwood C, Floyd K, Lai L, Davis-Gardner ME, Hudson WH, Mantus G, Nyhoff LE, Adelman MW, Fineman R, Patel S, Byram R, Gomes DN, Michael G, Abdullahi H, Beydoun N, Panganiban B, McNair N, Hellmeister K, Pitts J, Winters J, Kleinhenz J, Usher J, O'Keefe JB, Piantadosi A, Waggoner JJ, Babiker A, Stephens DS, Anderson EJ, Edupuganti S, Rouphael N, Ahmed R, Wrammert J, Suthar MS. Edara VV, et al. Among authors: floyd k. Cell Host Microbe. 2021 Apr 14;29(4):516-521.e3. doi: 10.1016/j.chom.2021.03.009. Epub 2021 Mar 20. Cell Host Microbe. 2021. PMID: 33798491 Free PMC article.
Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.
Cohen KW, Linderman SL, Moodie Z, Czartoski J, Lai L, Mantus G, Norwood C, Nyhoff LE, Edara VV, Floyd K, De Rosa SC, Ahmed H, Whaley R, Patel SN, Prigmore B, Lemos MP, Davis CW, Furth S, O'Keefe J, Gharpure MP, Gunisetty S, Stephens KA, Antia R, Zarnitsyna VI, Stephens DS, Edupuganti S, Rouphael N, Anderson EJ, Mehta AK, Wrammert J, Suthar MS, Ahmed R, McElrath MJ. Cohen KW, et al. Among authors: floyd k. medRxiv [Preprint]. 2021 Jun 18:2021.04.19.21255739. doi: 10.1101/2021.04.19.21255739. medRxiv. 2021. PMID: 33948610 Free PMC article. Updated. Preprint.
Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain.
Mantus G, Nyhoff LE, Kauffman RC, Edara VV, Lai L, Floyd K, Shi PY, Menachery VD, Edupuganti S, Scherer EM, Kay A, McNair N, Anderson EJ, Rouphael N, Ahmed R, Suthar MS, Wrammert J. Mantus G, et al. Among authors: floyd k. J Immunol. 2021 Jun 1;206(11):2605-2613. doi: 10.4049/jimmunol.2001420. Epub 2021 May 5. J Immunol. 2021. PMID: 33952616 Free PMC article.
CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection.
Vanderheiden A, Thomas J, Soung AL, Davis-Gardner ME, Floyd K, Jin F, Cowan DA, Pellegrini K, Creanga A, Pegu A, Derrien-Colemyn A, Shi PY, Grakoui A, Klein RS, Bosinger SE, Kohlmeier JE, Menachery VD, Suthar MS. Vanderheiden A, et al. Among authors: floyd k. bioRxiv [Preprint]. 2021 May 4:2021.05.03.442538. doi: 10.1101/2021.05.03.442538. bioRxiv. 2021. PMID: 33972938 Free PMC article. Updated. Preprint.
SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
Routhu NK, Cheedarla N, Bollimpelli VS, Gangadhara S, Edara VV, Lai L, Sahoo A, Shiferaw A, Styles TM, Floyd K, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Dinnon KH 3rd, Shi PY, Menachery VD, Tomai M, Fox CB, Alter G, Vanderford TH, Gralinski L, Suthar MS, Amara RR. Routhu NK, et al. Among authors: floyd k. Nat Commun. 2021 Jun 11;12(1):3587. doi: 10.1038/s41467-021-23942-y. Nat Commun. 2021. PMID: 34117252 Free PMC article.
292 results