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Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).
Koren MJ, Moriarty PM, Baum SJ, Neutel J, Hernandez-Illas M, Weintraub HS, Florio M, Kassahun H, Melquist S, Varrieur T, Haldar SM, Sohn W, Wang H, Elliott-Davey M, Rock BM, Pei T, Homann O, Hellawell J, Watts GF. Koren MJ, et al. Among authors: florio m. Nat Med. 2022 Jan;28(1):96-103. doi: 10.1038/s41591-021-01634-w. Epub 2022 Jan 13. Nat Med. 2022. PMID: 35027752 Clinical Trial.
Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease.
Murray JK, Long J, Liu L, Singh S, Pruitt D, Ollmann M, Swearingen E, Hardy M, Homann O, Wu B, Holder JR, Sham K, Herberich B, Lo MC, Dou H, Shkumatov A, Florio M, Rulifson IC. Murray JK, et al. Among authors: florio m. Nucleic Acid Ther. 2021 Oct;31(5):324-340. doi: 10.1089/nat.2021.0026. Epub 2021 Jul 23. Nucleic Acid Ther. 2021. PMID: 34297902
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.
Florio M, Gunasekaran K, Stolina M, Li X, Liu L, Tipton B, Salimi-Moosavi H, Asuncion FJ, Li C, Sun B, Tan HL, Zhang L, Han CY, Case R, Duguay AN, Grisanti M, Stevens J, Pretorius JK, Pacheco E, Jones H, Chen Q, Soriano BD, Wen J, Heron B, Jacobsen FW, Brisan E, Richards WG, Ke HZ, Ominsky MS. Florio M, et al. Nat Commun. 2016 May 27;7:11505. doi: 10.1038/ncomms11505. Nat Commun. 2016. PMID: 27230681 Free PMC article.
TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways.
Guerrero F, Herencia C, Almadén Y, Martínez-Moreno JM, Montes de Oca A, Rodriguez-Ortiz ME, Diaz-Tocados JM, Canalejo A, Florio M, López I, Richards WG, Rodriguez M, Aguilera-Tejero E, Muñoz-Castañeda JR. Guerrero F, et al. Among authors: florio m. PLoS One. 2014 Feb 27;9(2):e89179. doi: 10.1371/journal.pone.0089179. eCollection 2014. PLoS One. 2014. PMID: 24586576 Free PMC article.
Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease.
Manaud G, Nossent EJ, Lambert M, Ghigna MR, Boët A, Vinhas MC, Ranchoux B, Dumas SJ, Courboulin A, Girerd B, Soubrier F, Bignard J, Claude O, Lecerf F, Hautefort A, Florio M, Sun B, Nadaud S, Verleden SE, Remy S, Anegon I, Bogaard HJ, Mercier O, Fadel E, Simonneau G, Vonk Noordegraaf A, Grünberg K, Humbert M, Montani D, Dorfmüller P, Antigny F, Perros F. Manaud G, et al. Among authors: florio m. Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC. Am J Respir Cell Mol Biol. 2020. PMID: 32209028 Free article.
Ouabainlike factor in Milan hypertensive rats.
Ferrandi M, Minotti E, Salardi S, Florio M, Bianchi G, Ferrari P. Ferrandi M, et al. Among authors: florio m. Am J Physiol. 1992 Oct;263(4 Pt 2):F739-48. doi: 10.1152/ajprenal.1992.263.4.F739. Am J Physiol. 1992. PMID: 1329560
132 results