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Page 1
Aminothiazoles as γ-secretase modulators.
Lübbers T, Flohr A, Jolidon S, David-Pierson P, Jacobsen H, Ozmen L, Baumann K. Lübbers T, et al. Among authors: flohr a. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6554-8. doi: 10.1016/j.bmcl.2011.08.060. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21924610
4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists.
Cheung AW, Brinkman J, Firooznia F, Flohr A, Grimsby J, Gubler ML, Guertin K, Hamid R, Marcopulos N, Norcross RD, Qi L, Ramsey G, Tan J, Wen Y, Sarabu R. Cheung AW, et al. Among authors: flohr a. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4140-6. doi: 10.1016/j.bmcl.2010.05.056. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20541935
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C. Page RM, et al. Among authors: flohr a. J Biol Chem. 2008 Jan 11;283(2):677-83. doi: 10.1074/jbc.M708754200. Epub 2007 Oct 24. J Biol Chem. 2008. PMID: 17962197 Free article.
Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.
Luistro L, He W, Smith M, Packman K, Vilenchik M, Carvajal D, Roberts J, Cai J, Berkofsky-Fessler W, Hilton H, Linn M, Flohr A, Jakob-Røtne R, Jacobsen H, Glenn K, Heimbrook D, Boylan JF. Luistro L, et al. Among authors: flohr a. Cancer Res. 2009 Oct 1;69(19):7672-80. doi: 10.1158/0008-5472.CAN-09-1843. Epub 2009 Sep 22. Cancer Res. 2009. PMID: 19773430 Free PMC article.
45 results